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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Perinatal asphyxia: Kidney failure does not affect S100B urine concentrations
Clinica Chimica Acta, Volume 413, No. 1-2, Year 2012
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Description
Background: S100B protein is a well-established marker of brain damage. Its importance in urine assessment is the convenience of a collection and sampling procedure that can be repeated without risk for the newborn. Since S100B is mainly eliminated by the kidneys and perinatal asphyxia (PA) is often associated with kidney failure we investigated whether S100B release might be kidney-mediated, thereby modifying the protein's reliability as a brain-damage marker. Methods: We examined a cohort of healthy (n = 432) and asphyxiated newborns (n = 32) in whom kidney function parameters (blood urea and creatinine concentrations and urine gravity) and urine S100B concentrations were assessed in the first hours after birth. Data were analyzed by multiple logistic regression analysis with S100B as independent variable among a variety of clinical and laboratory monitoring parameters. Results: S100B urine concentrations were significantly higher (P < 0.01) in PA newborns than controls. No significant correlations (P > 0.05, for all) between total urine S100B levels and kidney function parameters such as creatinine (r = 0.03), urea (r = 0.04) and urine gravity (r = 0.06) were found. Multiple logistic regression analysis of a series of clinical and laboratory monitoring parameters (odds ratio at sampling: 9.47) with S100B as independent variable showed a positive significant correlation only between S100B levels (P < 0.001) and the occurrence of PA. Conclusion: The present study shows that altered kidney function is not an adverse and/or confounding factor in urine S100B assessment and marks a new step towards the introduction of longitudinal monitoring of brain constituents in clinical practice. © 2011 Elsevier B.V.
Authors & Co-Authors
Risso, Francesco Maria
Italy, Genoa
Istituto Giannina Gaslini
Serpero, Laura Domenica
Italy, Genoa
Università Degli Studi Di Genova
Zimmermann, Luc J.I.
Netherlands, Maastricht
Faculty of Health, Medicine and Life Sciences
Gavilanes, Antonio Wenceslao Danilo
Netherlands, Maastricht
Faculty of Health, Medicine and Life Sciences
Frulio, Rosanna
Italy, Genoa
Istituto Giannina Gaslini
Michetti, Fabrizio
Italy, Rome
Università Cattolica Del Sacro Cuore, Campus Di Roma
Florio, Pasquale
Italy, Siena
Università Degli Studi Di Siena
Bashir, Moataza
Egypt, Giza
Cairo University
Iskander, Iman Fathi
Egypt, Giza
Cairo University
Mufeed, Hala
Egypt, Giza
Cairo University
Aboulgar, Hanna
Egypt, Giza
Cairo University
Gazzolo, Diego
Italy, Alessandria
Azienda Ospedaliera Nazionale Santi Antonio e Biagio e Cesare Arrigo
Statistics
Citations: 16
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.1016/j.cca.2011.09.011
ISSN:
00098981
e-ISSN:
18733492
Study Design
Cohort Study
Case-Control Study
Study Approach
Quantitative