Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Impaired Th1 immunity in ovarian cancer patients is mediated by TNFR2+ Tregs within the tumor microenvironment
Clinical Immunology, Volume 149, No. 1, Year 2013
Notification
URL copied to clipboard!
Description
Ovarian cancer is a prevalent gynecological malignancy with potent immune-suppression capabilities; regulatory T cells (Tregs) are significant contributors to this immune-suppression. As ovarian cancer patients present with high levels of TNF and Tregs expressing TNFR2 are associated with maximal suppressive capacity, we investigated TNFR2. + Tregs within these patients. Indeed, TNFR2. + Tregs from tumor-associated ascites were the most potent suppressor T cell fraction. They were abundantly present within the ascites and more suppressive than peripheral blood TNFR2. + Tregs in patients. The increased suppressive capacity can be explained by a distinct cell surface expression profile, which includes high levels of CD39, CD73, TGF-β and GARP. Additionally, CD73 expression level on TNFR2. + Tregs was inversely correlated with IFN-γ production by effector T cells. This Treg fraction can be selectively recruited into the ascites from the peripheral blood of patients. Targeting TNFR2. + Tregs may offer new approaches to enhance the poor survival rates of ovarian cancer. © 2013 Elsevier Inc.
Authors & Co-Authors
Flanagan, Katie L.
Australia, Clayton
Faculty of Medicine, Nursing and Health Sciences
Denmark, Copenhagen
Statens Serum Institut
Quinn, Michael Anthony
Australia, Melbourne
Royal Women's Hospital, Carlton
Plebanski, Magdalena
Australia, Clayton
Faculty of Medicine, Nursing and Health Sciences
Statistics
Citations: 101
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1016/j.clim.2013.07.003
ISSN:
15217035
Research Areas
Cancer