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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
High levels of circulating cardiac proteins indicate cardiac impairment in African children with severe Plasmodium falciparum malaria
Microbes and Infection, Volume 7, No. 11-12, Year 2005
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Description
A role of the heart in the pathophysiology of severe Plasmodium falciparum malaria has recently been suggested. The objective of the present study was to substantiate this finding in a large group of African children and to correlate results with metabolic conditions in these children. Furthermore, the impact of a potential cardiac impairment on outcome in severe cases was assessed. Results may have important implications on the currently ongoing debate on fluid management in severe malaria patients. Plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), heart-type fatty acid-binding protein (H-FABP), myoglobin and creatine kinase muscle-brain (CK-MB) were compared in 400 African children with severe and mild falciparum malaria. Plasma levels of these markers were correlated with lactate and glucose blood levels, indicators for hypovolemia, and with clinical outcome. Children suffering from severe malaria and children who died (n = 22) exhibited high to very high levels of cardiac markers, respectively. Cardiac factors themselves were not predictive of fatal outcome, while, in multivariate analysis, lactic acidosis was the most important biochemical predictor of death in the severe malaria group. Lactic acidosis and hypoglycemia, however, result in cardiac impairment as defined by elevated levels of circulating cardiac proteins. Our results point to hypovolemia as a major underlying cause of lactic acidosis and hypoglycemia in African children with severe falciparum malaria. These deleterious metabolic conditions contribute to myocardial affection which was evident but not predictive per se of fatal outcome. © 2005 Elsevier SAS. All rights reserved.
Authors & Co-Authors
Ehrhardt, Stephan
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Mockenhaupt, Frank Peter
Germany, Berlin
Humboldt-universität zu Berlin
Anemana, Sylvester D.
Ghana, Accra
Ministry of Health Ghana
Otchwemah, Rowland N.
Ghana, Tamale
University for Development Studies Ghana
Wichmann, Dominic
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Cramer, Jakob Peter
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Bienzle, Ulrich
Germany, Berlin
Humboldt-universität zu Berlin
Burchard, Gerd Dieter
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Brattig, N. W.
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Statistics
Citations: 51
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1016/j.micinf.2005.04.007
ISSN:
12864579
e-ISSN:
1769714X
Research Areas
Infectious Diseases
Maternal And Child Health
Noncommunicable Diseases