Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Candida krusei, a multidrug-resistant opportunistic fungal pathogen: Geographic and temporal trends from the ARTEMIS DISK Antifungal Surveillance Program, 2001 to 2005
Journal of Clinical Microbiology, Volume 46, No. 2, Year 2008
Notification
URL copied to clipboard!
Description
Candida krusei is well known as a fungal pathogen for patients with hematologic malignancies and for transplant recipients. Using the ARTEMIS Antifungal Surveillance Program database, we describe geographic and temporal trends in the isolation of C. krusei from clinical specimens and the in vitro susceptibilities of 3,448 isolates to voriconazole as determined by CLSI (formerly NCCLS) disk diffusion testing. In addition, we report the in vitro susceptibilities of bloodstream infection isolates of C. krusei to amphotericin B (304 isolates), flucytosine (254 isolates), anidulafungin (121 isolates), caspofungin (300 isolates), and micafungin (102 isolates) as determined by CLSI broth microdilution methods. Geographic differences in isolation were apparent; the highest frequency of isolation was seen for the Czech Republic (7.6%) and the lowest for Indonesia, South Korea, and Thailand (0 to 0.3%). Overall, 83% of isolates were susceptible to voriconazole, ranging from 74.8% in Latin America to 92.3% in North America. C. krusei was most commonly isolated from hematology-oncology services, where only 76.7% of isolates were susceptible to voriconazole. There was no evidence of increasing resistance of C. krusei to voriconazole from 2001 to 2005. Decreased susceptibilities to amphotericin B (MIC at which 90% of isolates were inhibited [MIC90], 4 μg/ml) and flucytosine (MIC90, 16 μg/ml) were noted, whereas 100% of isolates were inhibited by ≤2 μg/ml of anidulafungin (MIC 90,0.06 μg/ml), micafungin (MIC90, 0.12 μg/ml) or caspofungin (MIC90, 0.25 μg/ml). C. krusei is an uncommon but multidrug-resistant fungal pathogen. Among the systemically active antifungal agents, the echinocandins appear to be the most active against this important pathogen. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Pfaller, Michael A.
United States, Iowa City
University of Iowa Carver College of Medicine
Diekema, D. J.
United States, Iowa City
University of Iowa Carver College of Medicine
Gibbs, David L.
United States, Santa Barbara
Giles Scientific, Inc.
Newell, V. A.
United States, Santa Barbara
Giles Scientific, Inc.
Nagy, Erzsébet
Hungary, Szeged
Szegedi Tudományegyetem Szte
Dobiasova, Stanislava
Czech Republic, Ostrava
Zdravotního Ústavu se Sídlem V Ostrave
Czech Republic, Ostrava
Zdravotni Ustav se Sidlem Ostrave
Rinaldi, Michael G.
United States, San Antonio
University of Texas Health Science Center at San Antonio
Barton, R.
United Kingdom, Leeds
Leeds General Infirmary
Veselov, A.
Russian Federation, Moscow
Institute of Antimicrobial Chemotherapy
Finquelievich, Jorge Luis
Argentina, Buenos Aires
Universidad de Buenos Aires
Tiraboschi, Nora
Argentina, Buenos Aires
Hospital Gral
Ellis, David H.
Australia, Adelaide
Women's and Children's Hospital Adelaide
Fameree, Dominique
Belgium, Jumet
Chu de Jumet
van den Abeele, Anne Marie
Unknown Affiliation
Senterre, Jean Marc
Belgium, Liege
Centre Hospitalier Regional de la Citadelle
Colombo, Arnaldo Lopes
Brazil, Sao Paulo
Universidade Federal de São Paulo
Rennie, Robert
Canada, Edmonton
University of Alberta Hospital
Sanche, Stephen E.
Canada, Saskatoon
Royal University Hospital
Bijie, Hu
China, Shanghai
Zhongshan Hospital
Xu, Yingchun
China, Beijing
Peking Union Medical College Hospital
Fu, Wang
China, Shanghai
Huashan Hospital
Zhong, Nanshan
China, Guangzhou
Guangzhou Institute of Repiratory Disease
Rivas, Pilar
Colombia, Bogota
Instituto Nacional de Cancerología
de Bedout, Catalina
Colombia, Medellin
Cib
Méndez, Matilde
Colombia, Bogota
Hospital Militar Central, Bogota
Vega, Ricardo
Colombia, Bogota
Hospital Militar Central, Bogota
Mallátová, Nadja
Czech Republic, Ceske Budejovice
Hospital Ceske Budejovice
Ayabaca, Julio
Ecuador, Quito
Hospital ff
Zurita, Jeannete
Ecuador, Quito
Hospital Vozandes
Mallié, Michèle
Unknown Affiliation
Candolfi, Ermanno
France, Strasbourg
Institut de Parasitologie
Fegeler, Wolfgang
Germany, Munster
University of Münster
Haase, P. D.G.
Germany, Aachen
Rheinisch-westfälische Technische Hochschule Aachen
Rodloff, Arne Christian
Germany, Leipzig
Inst. Fur Med. Mikrobiol./infekt.
Bar, W.
Germany, Cottbus
Carl-thiem-klinikum
Czaika, V.
Germany, Bad Saarow
Humaine Kliniken
Petrikos, George
Greece, Athens
Laikon General Hospital
Puskás, Erzsébet
Hungary, Miskolc
Baz County Institute
Doczi, I.
Hungary, Szeged
Szegedi Tudományegyetem Szte
Mestyan, Gyula
Hungary, Pecs
Pécsi Tudományegyetem
Nikolova, Radka
Hungary, Budapest
Szent Laszlo Hospital
Banerjee, Uma
India, New Delhi
All India Institute of Medical Sciences, new Delhi
Keller, Nathan
Israel, Tel Hashomer Tel Aviv
Chaim Sheba Medical Center Israel
Tullio, Vivian
Italy, Turin
Università Degli Studi Di Torino
Carlo Schito, Gian
Italy, Genoa
Università Degli Studi Di Genova
D'Antonio, Domenico
Italy, Pescara
Ospedale Civile Di Pescara
Martino, Pietro
Italy, Rome
Departamento Di Biotechnologia
Ng, Kee Peng
Malaysia, Kuala Lumpur
Universiti Malaya
Alpuche, Celia
Mexico, Acapulco
Secretaria de Salud
Santos, Jose
Mexico, Acapulco
Secretaria de Salud
Morfin Ortero, Rayo
Mexico, Guadalajara
Universidad de Guadalajara
Zaidi Jacobson, Mussaret Bano
Mexico, Merida
Hospital General O'horan
Meis, Jacques F.
Netherlands, Nijmegen
Canisius Wilhelmina Ziekenhuis
Lingaas, Egil
Norway, Oslo
Rikshospitalet-radiumhospitalet hf
Dzierźanowska, Danuta
Poland, Warsaw
Instytut Pomnik - Centrum Zdrowia Dziecka
Pawliszyn, Waclaw
Poland, Krakow
Pracownia Bakteriologii
Luz Martins, Mariada
Portugal, Lisbon
Instituto de Higiene e Medicina Tropical
Albuquerque, Luis
Portugal, Coimbra
Centro Hospitalar e Universitário de Coimbra
Rosado, Laura
Portugal, Lisbon
Instituto Nacional de Saúde Dr. Ricardo Jorge
Velho, Rosa
Portugal, Coimbra
Centro Hospitalar e Universitário de Coimbra
Amorim, Jose
Portugal, Porto
Hospital de Santo António
Ilina, Vera N.
Russian Federation, Moscow
National Medical Research Center for Hematology
Kretchikova, Olga I.
Russian Federation, Moscow
Institute of Antimicrobial Chemotherapy
Klyasova, Galina
Russian Federation, Moscow
National Medical Research Center for Hematology
Rozanova, Sophia M.
Russian Federation, Saint Petersburg
North-western State Medical University Named After I.i. Mechnikov
Multykh, Irina G.
Russian Federation, Krasnodar
Territory Center of Laboratory Diagnostics
Klimko, Nicholai Nikolaevich
Russian Federation, Saint Petersburg (ex Leningrad)
Medical Mycology Research Institute
Agapova, Elena D.
Russian Federation, Irkutsk
Irkutsk State Regional Children’s Clinical Hospital
Dmitrieva, Natalya V.
Russian Federation, Moscow
Oncology Research Center
Al Rasheed, Abdul Mohsen
Saudi Arabia, Riyadh
Riyadh Military Hospital
Shibl, Atef Mohamed A.
Saudi Arabia, Riyadh
King Saud University
Trupl, Ján
Slovakia, Bratislava
National Cancer Center
Helena, Hupkova
Slovakia, Bratislava
St. Cyril and Metod Hospital
Hoosen, Anwar Ahmed
South Africa, Pretoria
Sefako Makgatho Health Sciences University Smu
Wadula, Jeannette
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Janse van Rensburg, Marais N.
South Africa, Bloemfontein
University of the Free State
Dusé, Adriano Gianmaria
South Africa, Johannesburg
Charlotte Maxeke Johannesburg Academic Hospital
Lee, Kyungwon
South Korea, Seoul
Yonsei University College of Medicine
Kim, Mi Na
South Korea, Seoul
Asan Medical Center
del Palacio, Amalia
Spain, Madrid
Hospital Universitario 12 de Octubre
Sanchez-Sousa, Aurora
Spain, Madrid
Hospital Universitario Ramón y Cajal
Bille, Jacques
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Muhlethaler, K.
Switzerland, Bern
University of Bern
Chang, Shanchwen Chwen
Taiwan, Taipei
National Taiwan University Hospital
Wang, Jen Hsien
Taiwan, Taichung
China Medical University Hospital
Gu¨r, Deniz
Turkey, Ankara
Hacettepe Üniversitesi
Korten, Volkan
Turkey, Istanbul
Marmara Üniversitesi Tip Fakültesi
Paul, John M.
United Kingdom, Brighton
Royal Sussex County Hospital
Brown, Derek F.J.
United Kingdom, Cambridge
Addenbrooke's Hospital
Kibbler, Christopher C.
United Kingdom, London
The Royal Free Hospital
Weightman, Nigel C.
United Kingdom, Northallerton
Friarage Hospital
Gould, Ian Malcolm
United Kingdom, Aberdeen
Nhs Grampian
Rennison, Claire
United Kingdom, Newcastle
Royal Victoria Infirmary
Barton, Richard
United Kingdom, Leeds
Leeds General Infirmary
Barnes, Rosemary
United Kingdom, Cardiff
Cardiff University
Vázquez, José A.
United States, Detroit
Henry Ford Hospital
Larone, Davise H.
United States, New York
Weill Cornell Medical Center
Rinaldi, Mike
United States, San Antonio
University of Texas Health Science Center at San Antonio
Reyes, Heidi
Venezuela
Hospital General Del Este Domingo Luciani
Statistics
Citations: 231
Authors: 99
Affiliations: 88
Identifiers
Doi:
10.1128/JCM.01915-07
ISSN:
00951137
Research Areas
Cancer