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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The prevalence of aortic calcification in Japanese compared to white and Japanese-American middle-aged men is confounded by the amount of cigarette smoking
International Journal of Cardiology, Volume 167, No. 1, Year 2013
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Description
Background: The prevalence of coronary artery calcification (CAC) in Japanese men is lower than in white and Japanese-American men. It is unclear if aortic calcification (AC) strongly linked to smoking is also lower in Japanese men who have many times higher smoking prevalence compared to US men. Methods: We conducted a population-based study of 903 randomly-selected men aged 40-49 years: 310 Japanese men in Kusatsu, Japan, 301 white men in Allegheny County, US, and 292 Japanese men in Hawaii, US (2002-2006). The presence of AC was assessed by electron-beam tomography. AC was defined as Agatston aortic calcium scores (AoCaS) > 0 and ≥ 100. Results: Japanese (35.8%) had significantly less AoCaS > 0 compared to both white (68.8%, p < 0.001) and Japanese-American (62.3%, p < 0.001) but similar AoCaS ≥ 100 (19.4%, 18.3%, 22.6%, respectively, p = 0.392). The pack-years of smoking, which was highest in Japanese, was the most important single associate of AC in all populations. Additionally age, low-density-lipoprotein cholesterol (LDL-C), and triglycerides in Japanese; body-mass index (BMI) in white; and BMI, LDL-C, hypertension, diabetes, and lipid medications in Japanese-American were independent associates of AC. The risk of AC using either cut points adjusted for pack-years of smoking and additional risk factors was lower in Japanese compared to both white and Japanese-American. AC and CAC had moderately positive and significant correlations in Japanese (r = 0.26), white (r = 0.39), and Japanese-American (r = 0.45). Conclusions: The prevalence of AC defined both > 0 and ≥ 100 was significantly lower in Japanese than in white and Japanese-American men after adjusting for cigarette smoking and additional risk factors. © 2011 Elsevier Ireland Ltd.
Authors & Co-Authors
El-Saed, Aiman
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Egypt, Mansoura
Mansoura University
Curb, Jess David
United States, Honolulu
University of Hawaiʻi at Mānoa
Kadowaki, Takashi
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Japan, Otsu
Shiga University of Medical Science
Okamura, Tomonori
Japan, Otsu
Shiga University of Medical Science
Japan, Tokyo
Keio University
Sutton-Tyrrell, Kim C.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Masaki, Kamal H.
United States, Honolulu
University of Hawaiʻi at Mānoa
Seto, Todd B.
United States, Honolulu
Queen's Medical Center Hawaii
Takamiya, Tomoko
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Choo, Jina A.
South Korea, Seoul
Korea University
Edmundowicz, Daniel
United States, Pittsburgh
University of Pittsburgh
Evans, Rhobert Wyn
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Fujiyoshi, Akira
Japan, Otsu
Shiga University of Medical Science
Nakamura, Yasuyuki
Japan, Kyoto
Kyoto Women's University
Miura, Katsuyuki
Japan, Otsu
Shiga University of Medical Science
Shin, Chol
South Korea, Seoul
Korea University
Kuller, Lewis H.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Ueshima, Hirotusugu U.
Japan, Otsu
Shiga University of Medical Science
Sekikawa, Akira
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Japan, Otsu
Shiga University of Medical Science
Statistics
Citations: 18
Authors: 18
Affiliations: 9
Identifiers
Doi:
10.1016/j.ijcard.2011.12.060
ISSN:
01675273
e-ISSN:
18741754
Research Areas
Noncommunicable Diseases
Substance Abuse
Study Design
Cross Sectional Study
Participants Gender
Male