Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
IL-4Rα-Associated Antigen Processing by B Cells Promotes Immunity in Nippostrongylus brasiliensis Infection
PLoS Pathogens, Volume 9, No. 10, Article e1003662, Year 2013
Notification
URL copied to clipboard!
Description
In this study, B cell function in protective TH2 immunity against N. brasiliensis infection was investigated. Protection against secondary infection depended on IL-4Rα and IL-13; but not IL-4. Protection did not associate with parasite specific antibody responses. Re-infection of B cell-specific IL-4Rα-/- mice resulted in increased worm burdens compared to control mice, despite their equivalent capacity to control primary infection. Impaired protection correlated with reduced lymphocyte IL-13 production and B cell MHC class II and CD86 surface expression. Adoptive transfer of in vivo N. brasiliensis primed IL-4Rα expressing B cells into naïve BALB/c mice, but not IL-4Rα or IL-13 deficient B cells, conferred protection against primary N. brasiliensis infection. This protection required MHC class II compatibility on B cells suggesting cognate interactions by B cells with CD4+ T cells were important to co-ordinate immunity. Furthermore, the rapid nature of these protective effects by B cells suggested non-BCR mediated mechanisms, such as via Toll Like Receptors, was involved, and this was supported by transfer experiments using antigen pulsed Myd88-/- B cells. These data suggest TLR dependent antigen processing by IL-4Rα-responsive B cells producing IL-13 contribute significantly to CD4+ T cell-mediated protective immunity against N. brasiliensis infection. © 2013 Horsnell et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3812011/bin/ppat.1003662.s001.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3812011/bin/ppat.1003662.s002.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3812011/bin/ppat.1003662.s003.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3812011/bin/ppat.1003662.s004.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3812011/bin/ppat.1003662.s005.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3812011/bin/ppat.1003662.s006.tif
Authors & Co-Authors
Horsnell, William Gordon Charles
South Africa, Cape Town
University of Cape Town
Darby, Matthew G.
South Africa, Cape Town
University of Cape Town
Hoving, Jennifer Claire
South Africa, Cape Town
University of Cape Town
Nieuwenhuizen, Natalie Eva
South Africa, Cape Town
University of Cape Town
McSorley, Henry J.
United Kingdom, Edinburgh
The University of Edinburgh
Ndlovu, Hlumani H.
South Africa, Cape Town
University of Cape Town
Bobat, Saeeda
United Kingdom, Birmingham
University of Birmingham
Kimberg, Matti
South Africa, Cape Town
University of Cape Town
Kirstein, Frank
South Africa, Cape Town
University of Cape Town
Cutler, Antony J.
South Africa, Cape Town
University of Cape Town
United Kingdom, London
Colindale Blood Centre
Dewals, Benjamin G.
South Africa, Cape Town
University of Cape Town
Belgium, Liege
Université de Liège
Cunningham, Adam F.
United Kingdom, Birmingham
University of Birmingham
Brombacher, Frank
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 32
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1371/journal.ppat.1003662
ISSN:
15537366
e-ISSN:
15537374