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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Anti-giardial activity of gastrointestinal remedies of the Luo of East Africa
Journal of Ethnopharmacology, Volume 46, No. 1, Year 1995
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Description
Activity in an in vitro assay with Giardia lamblia provided a test of the validity of a quantitative methodology used in an ethnobotanical survey of the Luo people of the Lake Victoria basin of Kenya and Tanzania. Forty-five taxa of remedies for gastrointestinal problems were reported by four or more independent informants and a log-linear model was used to calculate a statistical measure of informant consensus. Methanolic extracts of 21 of 36 taxa assayed were lethal or inhibited growth of Giardia trophozoites at 1000 ppm; 7 species were lethal at 500 ppm. Non-cathartic species are more likely to be active than cathartics. Lethal species of non-cathartics are reported by informants more frequently than non-lethal species although the lack of statistical significance did not provide satisfactory support for the validity of the quantitative methodology as a predictor of efficacious remedies. © 1995.
Authors & Co-Authors
Johns, Timothy A.
Canada, Sainte-anne-de-bellevue
Centre for Indigenous Peoples' Nutrition and Environment
Faubert, Gaetan M.
Canada, Sainte-anne-de-bellevue
Mcgill University, Macdonald Campus
Kokwaro, John Ongayo
Kenya, Nairobi
University of Nairobi
Mahunnah, Rogasian Lemmy Anselm
Tanzania, Dar es Salaam
Muhimbili Medical Centre
Kimanani, Ebi K.
Canada, Ottawa
Nordion Inc.
Statistics
Citations: 94
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.1016/0378-8741(95)01224-2
ISSN:
03788741
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Multi-countries
Kenya
Tanzania