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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration
PLoS Medicine, Volume 2, Year 2005
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Description
Background: The genetic differences among HIV-1 subtypes may be critical to clinical management and drug resistance surveillance as antiretroviral treatment is expanded to regions of the world where diverse non-subtype-B viruses predominate. Methods and Findings: To assess the impact of HIV-1 subtype and antiretroviral treatment on the distribution of mutations in protease and reverse transcriptase, a binomial response model using subtype and treatment as explanatory variables was used to analyze a large compiled dataset of nonsubtype-B HIV-1 sequences. Non-subtype-B sequences from 3,686 persons with well characterized antiretroviral treatment histories were analyzed in comparison to subtype B sequences from 4,769 persons. The non-subtype-B sequences included 461 with subtype A, 1,185 with C, 331 with D, 245 with F, 293 with G, 513 with CRF01_AE, and 618 with CRF02_AG. Each of the 55 known subtype B drug-resistance mutations occurred in at least one non-B isolate, and 44 (80%) of these mutations were significantly associated with antiretroviral treatment in at least one non-B subtype. Conversely, of 67 mutations found to be associated with antiretroviral therapy in at least one non-B subtype, 61 were also associated with antiretroviral therapy in subtype B isolates. Conclusion: Global surveillance and genotypic assessment of drug resistance should focus primarily on the known subtype B drug-resistance mutations. Copyright: © 2005 Kantor et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC1087220/bin/pmed.0020112.sd001.pdf
Authors & Co-Authors
Kantor, Rami
United States, Palo Alto
Stanford University
United States, Providence
Brown University
Katzenstein, David A.
United States, Palo Alto
Stanford University
Efron, Bradley
United States, Palo Alto
Stanford University
Carvalho, Ana Patrícia
Portugal, Lisbon
Centro Hospitalar de Lisboa Ocidental Hospital de Egas Moniz
Wynhoven, Brian
Canada, Vancouver
British Columbia Centre for Excellence in Hiv-aids
Cane, Patricia A.
United Kingdom, London
Public Health England
Clarke, John R.
United Kingdom, London
St Mary's Hospital
Sirivichayakul, Sunee
Thailand, Bangkok
Chulalongkorn University
Soares, Marcelo Alves
Brazil, Rio de Janeiro
Universidade Federal do Rio de Janeiro
Snoeck, Joke
Belgium, Leuven
Rega Institute for Medical Research
Pillay, Candice
South Africa, Johannesburg
National Institute for Communicable Diseases
Rudich, Hagit
Israel, Jerusalem
Ministry of Health
Rodrigues, Rosângela
Brazil, Cerqueira Cesar
Instituto Adolfo Lutz
Holgúin, África
Spain, Madrid
Hospital Universitario la Paz
Ariyoshi, Koya
Japan, Tokyo
National Institute of Infectious Diseases
Bouzas, María Belén
Argentina, Buenos Aires
Fundacion Huesped
Cahn, Pedro Enrique
Argentina, Buenos Aires
Fundacion Huesped
Sugiura, Wataru
Japan, Tokyo
National Institute of Infectious Diseases
Soriano, Vicente Vicente
Spain, Madrid
Hospital Universitario la Paz
Brígido, Luís Fernando Macedo
Brazil, Cerqueira Cesar
Instituto Adolfo Lutz
Grossman, Zehava
Israel, Jerusalem
Ministry of Health
Morris, Lynn
South Africa, Johannesburg
National Institute for Communicable Diseases
Vandamme, Anne Mieke
Belgium, Leuven
Rega Institute for Medical Research
Tanuri, Amílcar
Brazil, Rio de Janeiro
Universidade Federal do Rio de Janeiro
Phanuphak, Praphan
Thailand, Bangkok
Chulalongkorn University
Weber, Jonathan N.
United Kingdom, London
St Mary's Hospital
Morris, Lynn G.
United Kingdom, London
University College London
Harrigan, P. Richard
Canada, Vancouver
British Columbia Centre for Excellence in Hiv-aids
Camacho, Ricardo Jorge
Portugal, Lisbon
Centro Hospitalar de Lisboa Ocidental Hospital de Egas Moniz
Schapiro, Jonathan M.
United States, Palo Alto
Stanford University
Shafer, Robert William
United States, Palo Alto
Stanford University
Statistics
Citations: 334
Authors: 31
Affiliations: 16
Identifiers
Doi:
10.1371/journal.pmed.0020112
ISSN:
15491277
Research Areas
Genetics And Genomics
Infectious Diseases