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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A Multifactorial Role for P. falciparum Malaria in Endemic Burkitt's Lymphoma Pathogenesis
PLoS Pathogens, Volume 10, No. 5, Article e1004170, Year 2014
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Description
Endemic Burkitt's lymphoma (eBL) arises from the germinal center (GC). It is a common tumor of young children in tropical Africa and its occurrence is closely linked geographically with the incidence of P. falciparum malaria. This association was noted more than 50 years ago. Since then we have learned that eBL contains the oncogenic herpes virus Epstein-Barr virus (EBV) and a defining translocation that activates the c-myc oncogene. However the link to malaria has never been explained. Here we provide evidence for a mechanism arising in the GC to explain this association. Accumulated evidence suggests that eBL arises in the GC when deregulated expression of AID (Activation-induced cytidine deaminase) causes a c-myc translocation in a cell latently infected with Epstein-Barr virus (EBV). Here we show that P. falciparum targets GC B cells via multiple pathways to increase the risk of eBL. 1. It causes deregulated expression of AID, thereby increasing the risk of a c-myc translocation. 2. It increases the number of B cells transiting the GC. 3. It dramatically increases the frequency of these cells that are infected with EBV and therefore protected from c-myc induced apoptosis. We propose that these activities combine synergistically to dramatically increase the incidence of eBL in individuals infected with malaria. © 2014 Torgbor et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4038605/bin/ppat.1004170.s001.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC4038605/bin/ppat.1004170.s002.docx
Authors & Co-Authors
Torgbor, Charles
United States, Boston
Tufts University School of Medicine
Ghana, Kumasi
Kumasi Centre for Collaborative Research in Tropical Medicine Kccr
Awuah, Peter C.
Ghana, Kumasi
Komfo Anokye Teaching Hospital
Deitsch, Kirk William
United States, New York
Weill Cornell Medicine
Kalantari, Parisa
United States, Worcester
University of Massachusetts Chan Medical School
Duca, Karen A.
Ghana, Kumasi
Kumasi Centre for Collaborative Research in Tropical Medicine Kccr
Thorley-Lawson, David A.
United States, Boston
Tufts University School of Medicine
Statistics
Citations: 92
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1371/journal.ppat.1004170
ISSN:
15537366
e-ISSN:
15537374
Research Areas
Cancer
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study