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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The use of the diaphragm instead of condoms in a phase III diaphragm trial
AIDS and Behavior, Volume 13, No. 3, Year 2009
Notification
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Description
The MIRA trial assessed whether providing diaphragm, lubricant gel, and condoms (intervention) compared with condoms alone (control) could reduce HIV incidence among 5,039 Southern African women. Compared with the control group, the cumulative proportion of last sex acts protected by any method was higher in the intervention group (OR = 1.33; 95% CI 1.18, 1.49); however, only 36.3% of last sex acts were protected by both a male condom and a diaphragm, whereas 36.6% were protected by a diaphragm only. Product substitution (ever deciding to use a diaphragm instead of a condom in the previous 3 months) was reported at every visit by 22.4%, at some visits by 60.7%, and at none of the visits by 16.8% of these women. Women at greater risk for infection through their own or their partner's behavior or who believed the diaphragm protected against HIV were more likely to report product substitution at every visit. © 2008 Springer Science+Business Media, LLC.
Authors & Co-Authors
van der Straten, Ariane
United States, Research Triangle Park
Rti International
United States, San Francisco
Ucsf School of Medicine
Cheng, Helen Y.
United States, Research Triangle Park
Rti International
Moore, Jie G.
United States, San Francisco
University of California, San Francisco
Kacanek, Deborah
United States, Cambridge
Ibis Reproductive Health
Blanchard, Kelly
United States, Cambridge
Ibis Reproductive Health
De Bruyn, Guy
South Africa, Johannesburg
University of the Witwatersrand
Ramjee, Gita A.
South Africa, Tygerberg
South African Medical Research Council
Chipato, Tsungai
Zimbabwe, Harare
University of Zimbabwe
Montgomery, Elizabeth T.
United States, Research Triangle Park
Rti International
Padian, Nancy S.
United States, Research Triangle Park
Rti International
Statistics
Citations: 18
Authors: 10
Affiliations: 7
Identifiers
Doi:
10.1007/s10461-008-9504-z
ISSN:
10907165
Research Areas
Infectious Diseases
Study Design
Randomised Control Trial
Cohort Study
Participants Gender
Male
Female