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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Genetic characteristics of HIV-1 subtype C envelopes inducing cross-neutralizing antibodies
Virology, Volume 368, No. 1, Year 2007
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Description
This study aimed to characterize genetic features of HIV-1 subtype C envelope glycoproteins capable of eliciting cross-reactive neutralizing antibodies during natural infections. The gp160 sequences were determined for 36 HIV-1 subtype C isolates (donor viruses) from infected individuals residing in Malawi, Zimbabwe, Zambia and South Africa, whose sera displayed a range of cross-neutralizing activities against a panel of 5 subtype C and 5 subtype B viruses (panel viruses). Hierarchical clustering analysis of neutralization data of the panel viruses predicted phylogenetic relationships between subtype B and C panel viruses, suggesting some subtype-specific neutralization determinants. A similar comparison of subtype C donor viruses showed no significant correlation; however of three donor sequence pairs resolvable by phylogenetic analysis, two were also associated within the neutralization clustering dendrogram, suggesting that closely related viruses may elicit antibodies targeting common neutralization determinants. Significantly, viruses that had shorter V1-V4 loops induced antibodies that showed more neutralization breadth against the subtype C panel viruses (p = 0.0135). This study indicates that that some structural features of envelope, such as shorter variable loops, may facilitate the elicitation of cross-reactive neutralizing antibodies in natural infections. Collectively these data provide some insights into design features of an envelope immunogen aimed at inducing neutralizing antibodies. © 2007 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Rademeyer, Cecilia
South Africa, Cape Town
University of Cape Town
Moore, Penny L.
South Africa, Johannesburg
National Institute for Communicable Diseases
Taylor, Natasha
South Africa, Johannesburg
National Institute for Communicable Diseases
Martin, Darren Patrick
South Africa, Cape Town
University of Cape Town
Choge, Isaac A.
South Africa, Johannesburg
National Institute for Communicable Diseases
Gray, Elin Solomonovna
South Africa, Johannesburg
National Institute for Communicable Diseases
Sheppard, Haynes W.
United States, Davis
University of California, Davis
Gray, Clive M.
South Africa, Johannesburg
National Institute for Communicable Diseases
Morris, Lynn
South Africa, Johannesburg
National Institute for Communicable Diseases
Williamson, Carolyn
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 54
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1016/j.virol.2007.06.013
ISSN:
00426822
e-ISSN:
10960341
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Malawi
South Africa
Zambia
Zimbabwe