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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Novel self-assembled amphiphilic poly(ε-caprolactone)-grafted- poly(vinyl alcohol) nanoparticles: Hydrophobic and hydrophilic drugs carrier nanoparticles
Journal of Materials Science: Materials in Medicine, Volume 20, No. 3, Year 2009
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Description
In the present study, we have aimed to produce nanoparticles (NPs) possessing the capability of carrying both of the hydrophobic and hydrophilic drugs and reveal significant release for both drug types. Poly(ε- caprolactone) (PCL) grafted poly(vinyl alcohol) (PVA) copolymer (PCL-g-PVA) has been prepared and shaped in nano-particulate form to be adequate for carrying the drugs. Stannous octoate (Sn(II)Oct2) was used to catalyze PVA and ε-caprolactone monomer to chemically bond. Moreover, this catalyst enhanced side chain polymerization reaction for the utilized ε-caprolactone monomer to form poly(ε-caprolactone) (PCL). The formed PCL was attached as branches with PVA backbone. 1H NMR has confirmed formation of PCL and grafting of PVA by this new polymer. Moreover, the vibration modes in the functional groups of PCL-g-PVA have been detected by FT-IR. The thermal alteration in the grafted polymer was checked by TGA analysis. The successfully synthesized grafted copolymer was able to self-aggregate into NPs by direct dialysis method. The size, morphology and charges associated with the obtained NPs were analyzed by DLS, TEM and ELS, respectively. PCL-g-PVA NPs were investigated as drug carrier models for hydrophobic and hydrophilic anti cancer drugs; paclitaxel and doxorubicin. In vitro drug release experiments were conducted; the loaded NPs reveal continuous and sustained release form for both drugs, up to 20 and 15 days for paclitaxel and doxorubicin, respectively. However, in a case of using pure drugs only, both drugs completely released within 1-2 h. The overall obtained results strongly recommend the use these novel NPs in future drug delivery systems. © 2008 Springer Science+Business Media, LLC.
Authors & Co-Authors
Sheikh, Faheem Arjamend
South Korea, Jeonju
Jeonbuk National University
Barakat, Nasser A.M.
Egypt, Minya
Faculty of Engineering
South Korea, Jeonju
Jeonbuk National University
Kanjwal, Muzafar A.
South Korea, Jeonju
Jeonbuk National University
Aryal, Santosh
United States, Milwaukee
University of Wisconsin-milwaukee
Khil, Myungseob
South Korea, Jeonju
Jeonbuk National University
Kim, Hakyong
South Korea, Jeonju
Jeonbuk National University
Statistics
Citations: 67
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1007/s10856-008-3637-5
Research Areas
Cancer
Noncommunicable Diseases
Substance Abuse