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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Male circumcision significantly reduces prevalence and load of genital anaerobic bacteria
mBio, Volume 4, No. 2, Article e00076-13, Year 2013
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Description
Male circumcision reduces female-to-male HIV transmission. Hypothesized mechanisms for this protective effect include decreased HIV target cell recruitment and activation due to changes in the penis microbiome. We compared the coronal sulcus microbiota of men from a group of uncircumcised controls (n77) and from a circumcised intervention group (n79) at enrollment and year 1 follow-up in a randomized circumcision trial in Rakai, Uganda. We characterized microbiota using16S rRNA gene-based quantitative PCR (qPCR) and pyrosequencing, log response ratio (LRR), Bayesian classification, nonmetric multidimensional scaling (nMDS), and permutational multivariate analysis of variance (PerMANOVA). At baseline, men in both study arms had comparable coronal sulcus microbiota; however, by year 1, circumcision decreased the total bacterial load and reduced microbiota biodiversity. Specifically, the prevalence and absolute abundance of 12 anaerobic bacterial taxa decreased significantly in the circumcised men. While aerobic bacterial taxa also increased postcircumcision, these gains were minor. The reduction in anaerobes may partly account for the effects of circumcision on reduced HIV acquisition. © 2013 Liu et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3634604/bin/mbo002131493s1.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3634604/bin/mbo002131493sf01.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3634604/bin/mbo002131493st1.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3634604/bin/mbo002131493st2.docx
Authors & Co-Authors
Liu, Cindy Meng Hsin
United States, Phoenix
Translational Genomics Research Institute
United States, Flagstaff
Northern Arizona University
United States, Baltimore
Johns Hopkins University
Hungate, Bruce A.
United States, Flagstaff
Northern Arizona University
Tobian, Aaron A.R.
United States, Baltimore
Johns Hopkins University
Serwadda, David Musoke
Unknown Affiliation
Ravel, Jacques
United States, Baltimore
University of Maryland, Baltimore Umb
Kigozi, Godfrey G.
Unknown Affiliation
Aziz, Maliha
United States, Phoenix
Translational Genomics Research Institute
Galiwango, Ronald Moses
Unknown Affiliation
Nalugoda, Fred Kakaire
Unknown Affiliation
Wawer, Maria J.
United States, Baltimore
Johns Hopkins University
Keim, Paul S.
United States, Phoenix
Translational Genomics Research Institute
United States, Flagstaff
Northern Arizona University
Gray, Ronald H.
United States, Baltimore
Johns Hopkins University
Price, Lance L. B.
United States, Phoenix
Translational Genomics Research Institute
United States, Washington, D.c.
The George Washington University
Statistics
Citations: 108
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1128/mBio.00076-13
ISSN:
21507511
Research Areas
Genetics And Genomics
Infectious Diseases
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Uganda
Participants Gender
Male
Female