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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Polyfunctional Mycobacterium tuberculosis-specific effector memory CD4+ T cells at sites of pleural TB
Tuberculosis, Volume 91, No. 3, Year 2011
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Description
Pleural tuberculosis (TB) is a common presentation of Mycobacterium tuberculosis (MTB) infection, and despite spontaneous resolution remains a strong risk factor for reactivation pulmonary TB in a majority of individuals. This study was undertaken to further understand the characteristics of immune cells at sites of pleural TB. A significant shift toward memory CD4+ T cells with an effector phenotype and away from naïve CD4+ T cells in pleural fluid as compared to blood mononuclear cells was found. These data suggest that effector T cells are capable of migrating to sites of active TB infection and/or the differentiation to effector phenotype T cells in situ is highly amplified. Using multi-parameter flow cytometry analysis, a significant portion of MTB-specific CD4+ T cells in the pleural space were polyfunctional demonstrating two, three or four simultaneous functions including IFN-gamma, IL-2, TNF-alpha, and or MIP-1 alpha production. A greater proportion of these polyfunctional cells were of effector memory rather than central memory phenotype. The role of these polyfunctional MTB-specific CD4+ T cells at sites of pleural TB requires further study. © 2010 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
El Fenniri, L.
Morocco, Agdal Rabat
Institut National D'hygine
Toossi, Zahra T.
United States, Cleveland
Case Western Reserve University
Aung, Htin
United States, Cleveland
Case Western Reserve University
El Iraki, G.
Morocco, Agdal Rabat
Hôpital Moulay Youssef
Bourkkadi, J.
Morocco, Agdal Rabat
Hôpital Moulay Youssef
Benamor, Jouda
Morocco, Agdal Rabat
Hôpital Moulay Youssef
Laskri, A.
Morocco, Agdal Rabat
Institut National D'hygine
Berrada, Noâma
Morocco, Rabat
Faculté Des Sciences Rabat
Benjouad, Abdelaziz
Morocco, Rabat
Faculté Des Sciences Rabat
Mayanja-Kizza, Harriet
Uganda, Kampala
Makerere University
Betts, Michael R.
United States, Philadelphia
University of Pennsylvania
El Aouad, Rajae
Morocco, Agdal Rabat
Institut National D'hygine
Canaday, David H.
Morocco, Agdal Rabat
Institut National D'hygine
United States, Cleveland
Case Western Reserve University
Statistics
Citations: 29
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1016/j.tube.2010.12.005
ISSN:
14729792
Research Areas
Infectious Diseases