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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
HIV and noncommunicable cardiovascular and pulmonary diseases in low-and middle-income countries in the art era: What we know and best directions for future research
Journal of Acquired Immune Deficiency Syndromes, Volume 67, No. SUPPL.1, Year 2014
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Description
With the advent of effective antiretroviral therapy (ART), HIV is becoming a chronic disease. HIV-seropositive (+) patients on ART can expect to live longer and, as a result, they are at risk of developing chronic noncommunicable diseases related to factors, such as aging, lifestyle, long-term HIV infection, and the potential adverse effects of ART. Although data are incomplete, evidence suggests that even in low-and middle-income countries (LMICs), chronic cardiovascular and pulmonary diseases are increasing in HIV-positive patients. This review summarizes evidence-linking HIV infection to the most commonly cited chronic cardiovascular and pulmonary conditions in LMICs: heart failure, hypertension, coronary artery disease/myocardial infarction, stroke, obstructive lung diseases, and pulmonary arterial hypertension. We describe the observed epidemiology of these conditions, factors affecting expression in LMICs, and key populations that may be at higher risk (ie, illicit drug users and children), and finally, we suggest that strategic areas of research and training intended to counter these conditions effectively. As access to ART in LMICs increases, long-term outcomes among HIV-positive persons will increasingly be determined by a range of associated chronic cardiovascular and pulmonary complications. Actions taken now to identify those conditions that contribute to long-term morbidity and mortality optimize early recognition and diagnosis and implement effective prevention strategies and/or disease interventions are likely to have the greatest impact on limiting cardiovascular and pulmonary disease comorbidity and improving population health among HIV-positive patients in LMICs. © 2014 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Bloomfield, Gerald Samuel
United States, Durham
Duke Clinical Research Institute
United States, Durham
Duke University
Khazanie, Prateeti
United States, Durham
Duke Clinical Research Institute
Morris, Alison M.
United States, Pittsburgh
University of Pittsburgh School of Medicine
Rabadán-Diehl, Cristina
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
Benjamin, Laura A.
United Kingdom, Liverpool
University of Liverpool
Malawi, Zomba
University of Malawi
Murdoch, David M.
United States, Seattle
Divisions of Pulmonary and Critical Care Medicine
Radcliff, Virginia S.
United States, Seattle
Divisions of Pulmonary and Critical Care Medicine
Velázquez, Eric Jose
United States, Durham
Duke Clinical Research Institute
United States, Durham
Duke University
Hicks, Charles B.
United States, Durham
Duke University
Statistics
Citations: 92
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1097/QAI.0000000000000257
ISSN:
15254135
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cross Sectional Study