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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A randomized dose-response trial of a single injection of corifollitropin alfa to sustain multifollicular growth during controlled ovarian stimulation
Human Reproduction, Volume 23, No. 11, Year 2008
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Description
BACKGROUND: This study primarily investigated the dose-response relationship of corifollitropin alfa to initiate multifollicular development for the first 7 days of controlled ovarian stimulation (COS). METHODS: Women aged 20-39 years undergoing COS for in vitro fertilization or intracytoplasmic sperm injection were randomized to a single dose of corifollitropin alfa 60, 120 or 180 μg, or daily injections of 150 IU recombinant follicle-stimulating hormone (rFSH). Patients treated with corifollitropin alfa started fixed daily treatment with 150 IU rFSH on stimulation Day 8. Patients received a GnRH antagonist (ganirelix 0.25 mg/day) from stimulation Day 5 until the day of human chorionic gonadotrophin. RESULTS: Pharmacokinetics of corifollitropin alfa were dose-proportional. The main reason for not having embryo transfer was insufficient ovarian response in 30.8, 2.6, 3.8 and 7.4% of patients in the corifollitropin alfa 60, 120, 180 μg and rFSH groups, respectively. On Day 8, the mean (standard deviation) number of follicles ≥11 mm was 6.8 (4.4), 10.1 (6.1) and 12.8 (7.5), respectively. The number of cumulus-oocyte complexes retrieved showed a clear dose-response relationship (P < 0.0001), being 5.2 (5.5), 10.3 (6.3) and 12.5 (8.0) in the three dose groups, respectively. CONCLUSIONS: A single injection of corifollitropin alfa induces dose-related increase in multifollicular development and in the number of retrieved oocytes. The optimal dose for a 1-week interval is higher than 60 μg and lower than 180 μg and will be selected based on modelling and simulation taking into account insufficient stimulation as well as overstimulation. Clinical Trials gov: NCT00598208. © The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Authors & Co-Authors
Balen, Adam H.
United Kingdom, Leeds
Leeds General Infirmary
DeVroey, Paul
Belgium, Brussels
Vrije Universiteit Brussel
D'Hooghe, Thomas Maria
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Fauser, Bart C.J.M.
Netherlands, Rotterdam
Erasmus Mc
Ombelet, Willem U.A.M.
Belgium, Genk
Ziekenhuis Oost-limburg
Tapanainen, Juha Samuli
Finland, Oulu
Oulu University Hospital
Varila, Eero
Unknown Affiliation
Statistics
Citations: 68
Authors: 7
Affiliations: 14
Identifiers
Doi:
10.1093/humrep/den288
ISSN:
02681161
Participants Gender
Female