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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Toxicity and mutagenic activity of some selected Nigerian plants
Journal of Ethnopharmacology, Volume 113, No. 3, Year 2007
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Description
The toxicity and mutagenic potential of most African plants implicated in the management of cancer have not been investigated. The ethanolic extracts of selected Nigerian plants were subsequently studied using the brine shrimp lethality tests, inhibition of telomerase activity and induction of chromosomal aberrations in vivo in rat lymphocytes. Morinda lucida root bark, Nymphaea lotus whole plant and Garcinia kola root were active in the three test systems. Bryophyllum calycinum whole plant, Annona senegalensis root, Hymenocardia acida stem bark, Erythrophleum suaveolens leaves and Spondiathus preussii stem bark were toxic to brine shrimps and caused chromosomal damage in rat lymphocytes. Ficus exasperata leaves, Chrysophyllum albidum root bark and Hibiscus sabdariffa leaves were non-toxic to all the three test systems. Chenopodium ambrosioides whole plant was non-toxic to brine shrimps and rat lymphocyte chromosomes but showed inhibition in the conventional telomerase assay indicating a possible selectivity for human chromosomes. The result justified the use of the first eight plants and Chenopodium ambrosioides in the management of cancer in south west Nigeria although they appear to be non-selective and their mode of action may be different from plant to plant. All these plants except Chenopodium ambrosioides are also mutagenic and cytotoxic. © 2007 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Sowemimo, Abimbola Adepeju
Nigeria, Ife
Obafemi Awolowo University
Fakoya, Francis Adelade
Nigeria, Ife
Obafemi Awolowo University
Awopetu, I.
Nigeria, Ife
Obafemi Awolowo University
Omobuwajo, Olanrewaju Rita Marie
Nigeria, Ife
Obafemi Awolowo University
Adesanya, Saburi A.
Nigeria, Ife
Obafemi Awolowo University
Statistics
Citations: 103
Authors: 5
Affiliations: 1
Identifiers
Doi:
10.1016/j.jep.2007.06.024
ISSN:
03788741
Research Areas
Cancer
Environmental
Study Locations
Nigeria