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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Diffusion-weighted imaging improves the diagnostic accuracy of conventional 3.0-T breast MR imaging
Radiology, Volume 256, No. 1, Year 2010
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Description
Purpose: To evaluate the incremental value of diffusion-weighted (DW) imaging and apparent diffusion coefficient (ADC) mapping in relation to conventional breast magnetic resonance (MR) imaging in the characterization of benign versus malignant breast lesions at 3.0 T. Materials and Methods: This retrospective HIPAA-compliant study was approved by the institutional review board, with the requirement for informed patient consent waived. Of 550 consecutive patients who underwent bilateral breast MR imaging over a 10-month period, 93 women with 101 lesions met the following study inclusion criteria: They had undergone three-dimensional (3D) high-spatial-resolution T1-weighted contrast material - enhanced MR imaging, dynamic contrastenhanced MR imaging, and DW imaging examinations at 3.0 T and either had received a pathologic analysis - proven diagnosis (96 lesions) or had lesion stability confirmed at more than 2 years of follow-up (five lesions). DW images were acquired with b values of 0 and 600 sec/mm2. Regions of interest were drawn on ADC maps of breast lesions and normal glandular tissue. Morphologic features (margin, enhancement pattern), dynamic contrast-enhanced MR results (semiquantitative kinetic curve data), absolute ADCs, and glandular tissue - normalized ADCs were included in multivariate models to predict a diagnosis of benign versus malignant lesion. Results: Forty-one (44%) of the 93 patients were premenopausal, and 52 (56%) were postmenopausal. Thirty-three (32.7%) of the 101 lesions were benign, and 68 (67.3%) were malignant. Normalized ADCs were significantly different between the benign (mean ADC, 1.1 × 10 -3 mm2/sec ± 0.4 [standard deviation]) and malignant (mean ADC, 0.55 × 10-3 mm2/sec ± 0.16) lesions (P < .001). Adding normalized ADCs to the 3D T1-weighted and dynamic contrast-enhanced MR data improved the diagnostic performance of MR imaging: The area under the receiver operating characteristic curve improved from 0.89 to 0.98, and the false-positive rate decreased from 36% (nine of 25 lesions) to 24% (six of 25 lesions). Conclusion: DW imaging with glandular tissue - normalized ADC assessment improves the characterization of breast lesions beyond the characterization achieved with conventional 3D T1-weighted and dynamic contrast-enhanced MR imaging at 3.0 T. © RSNA, 2010.
Authors & Co-Authors
El-Khouli, Riham H.
United States, Bethesda
National Institute of Biomedical Imaging and Bioengineering Nibib
United States, Baltimore
Johns Hopkins School of Medicine
Egypt, Ismailia
Faculty of Medicine
Jacobs, Michael A.
United States, Baltimore
Johns Hopkins School of Medicine
United States, Baltimore
The Sidney Kimmel Comprehensive Cancer Center
Mezban, Sarah D.
United States, Bethesda
National Institute of Biomedical Imaging and Bioengineering Nibib
Huang, Peng
United States, Bethesda
National Institute of Biomedical Imaging and Bioengineering Nibib
Kamel, Ihab R.
United States, Baltimore
Johns Hopkins School of Medicine
MacUra, Katarzyna Jadwiga
United States, Baltimore
Johns Hopkins School of Medicine
Bluemke, David A.
United States, Bethesda
National Institute of Biomedical Imaging and Bioengineering Nibib
United States, Baltimore
Johns Hopkins School of Medicine
Statistics
Citations: 260
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1148/radiol.10091367
ISSN:
00338419
e-ISSN:
15271315
Research Areas
Cancer
Health System And Policy
Study Design
Cohort Study
Participants Gender
Female