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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Polyfunctional T cell responses are a hallmark of HIV-2 infection
European Journal of Immunology, Volume 38, No. 2, Year 2008
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Description
HIV-2 is distinguished clinically and immunologically from HIV-1 infection by delayed disease progression and maintenance of HIV-specific CD4+ T cell help in most infected subjects. Thus, HIV-2 provides a unique natural human model in which to investigate correlates of immune protection against HIV disease progression. Here, we report a detailed assessment of the HIV-2-specific CD4+ and CD8+ T cell response compared to HIV-1, using polychromatic flow cytometry to assess the quality of the HIV-specific T cell response by measuring IFN-, IL-2, TNF-α, MIP-1β, and CD107a mobilization (degranulation) simultaneously following Gag peptide stimulation. We find that HIV-2-specific CD4+ and CD8+ T cells are more polyfunctional that those specific for HIV-1 and that polyfunctional HIV-2-specific T cells produce more IFN-γ and TNF-α on a per-cell basis than monofunctional T cells. Polyfunctional HIV-2-specific CD4+ T cells were generally more differentiated and expressed CD57, while there was no association between function and phenotype in the CD8+ T cell fraction. Polyfunctional HIV-specific T cell responses are a hallmark of non-progressive HIV-2 infection and may be related to good clinical outcome in this setting. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Authors & Co-Authors
Duvall, Melody G.
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Precopio, Melissa L.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Ambrozak, David R.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Jaye, Assan
Gambia, Banjul
Medical Research Council Laboratories Gambia
McMichael, Andrew James
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
Whittle, Hilton C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Roederer, Mario
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Rowland-Jones, Sarah Louise
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
Gambia, Banjul
Medical Research Council Laboratories Gambia
Koup, Richard A.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Statistics
Citations: 9
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1002/eji.200737768
Research Areas
Infectious Diseases