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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Merkel cell carcinoma: Descriptive study of 24 cases (1993-2001)
Revue de Medecine Interne, Volume 24, No. 9, Year 2003
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Description
Introduction. - Merkel cell carcinoma (MCC) is a rare skin tumor with a highly malignant nature whose appropriate treatment is still debated. Wide surgery is the treatment of choice, but the question concerning protocols for adjuvant radiotherapy or chemotherapy remains open. Patients and Methods. - A retrospective analysis of 24 cases of MCC collected over a period of 9 years was performed, focusing on clinical and histologic features, and response to treatment. Results. - There were 17 women and 7 men with a mean age of 74.3 years. The median follow up was 34 months. The annual incidence per 100,000 habitants was 0.378. The head and neck localization was predominant (54%). Fifteen (68%) of patients presented with local disease (stage I), and 32% of patients presented with regional node (stage II) or distant metastases (stage III). Patients with stage I had a 5-years overall survival rate of 73,85%. Among them, five patients (33%) developed a local or nodal recurrence, although two patients were initially treated with surgery and local post-operative radiotherapy. Patients with stage II and III demonstrated a 5-year overall survival rate of 51,43%. Discussion. - Our series illustrates the clinical characteristics of this tumor of the elderly, which is mainly located on head and neck and associated with a poor prognosis. Treatments are discussed. © 2003 Éditions scientifiques et médicales Elsevier SAS. Tous droits réservés.
Authors & Co-Authors
Benessahraoui, Mouna
France, Besancon
Centre Hospitalier Universitaire de Besançon
Dalstein, Véronique
France, Besancon
Centre Hospitalier Universitaire de Besançon
Lorchel, Fabrice
France, Besancon
Centre Hospitalier Universitaire de Besançon
Algros, Marie Paule
France, Besancon
Centre Hospitalier Universitaire de Besançon
Puzenat, Ève
France, Besancon
Centre Hospitalier Universitaire de Besançon
Louvat, P.
France, Besancon
Centre Hospitalier Universitaire de Besançon
Hassam, Badreddine
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Humbert, Philippe
France, Besancon
Centre Hospitalier Universitaire de Besançon
Aubin, François F.
France, Besancon
Centre Hospitalier Universitaire de Besançon
Statistics
Citations: 11
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1016/S0248-8663(03)00188-7
ISSN:
02488663
Research Areas
Cancer
Health System And Policy
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Male
Female