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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Hepatitis delta infection among persons living with HIV in Europe
Liver International, Volume 43, No. 4, Year 2023
Notification
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Description
Background and Aims: A high prevalence of hepatitis delta virus (HDV) infection, the most severe form of viral hepatitis, has been reported among persons living with HIV (PLWH) in Europe. We analysed data from a large HIV cohort collaboration to characterize HDV epidemiological trends across Europe, as well as its impact on clinical outcomes. Methods: All PLWH with a positive hepatitis B surface antigen (HBsAg) in the Swiss HIV Cohort Study and EuroSIDA between 1988 and 2019 were tested for anti-HDV antibodies and, if positive, for HDV RNA. Demographic and clinical characteristics at initiation of antiretroviral therapy were compared between HDV-positive and HDV-negative individuals using descriptive statistics. The associations between HDV infection and overall mortality, liver-related mortality as well as hepatocellular carcinoma (HCC) were assessed using cumulative incidence plots and cause-specific multivariable Cox regression. Results: Of 2793 HBsAg-positive participants, 1556 (56%) had stored serum available and were included. The prevalence of HDV coinfection was 15.2% (237/1556, 95% confidence interval [CI]: 13.5%–17.1%) and 66% (132/200) of HDV-positive individuals had active HDV replication. Among persons who inject drugs (PWID), the prevalence of HDV coinfection was 50.5% (182/360, 95% CI: 45.3%–55.7%), with similar estimates across Europe, compared to 4.7% (52/1109, 95% CI: 3.5%–5.9%) among other participants. During a median follow-up of 10.8 years (interquartile range 5.6–17.8), 82 (34.6%) HDV-positive and 265 (20.1%) HDV-negative individuals died. 41.5% (34/82) of deaths were liver-related in HDV-positive individuals compared to 17.7% (47/265) in HDV-negative individuals. HDV infection was associated with overall mortality (adjusted hazard ratio 1.6; 95% CI 1.2–2.1), liver-related death (2.9, 1.6–5.0) and HCC (6.3, 2.5–16.0). Conclusion: We found a very high prevalence of hepatitis delta among PWID across Europe. Among PLWH who do not inject drugs, the prevalence was similar to that reported from populations without HIV. HDV coinfection was associated with liver-related mortality and HCC incidence. © 2023 The Authors. Liver International published by John Wiley & Sons Ltd.
Authors & Co-Authors
Atkinson, Andrew
Switzerland, Bern
University of Bern
Boyd, Anders C.
Netherlands, Utrecht
Netherlands Public Health Service
Falconer, Karolin
Sweden, Stockholm
Karolinska Universitetssjukhuset
Günthard, Huldrych F.
Switzerland, Zurich
Universitatsspital Zurich
Switzerland, Zurich
Universität Zürich
Rockstroh, Jürgen Kurt
Germany, Bonn
Universitätsklinikum Bonn
Mocroft, Amanda J.
United Kingdom, London
University College London
Denmark, Copenhagen
Københavns Universitet
Rauch, Andri
Switzerland, Bern
University of Bern
Peters, Lars
Denmark, Copenhagen
Københavns Universitet
Wandeler, Gilles
Switzerland, Bern
University of Bern
Abela, Irène Alma
Unknown Affiliation
Aebi-Popp, Karoline
Unknown Affiliation
Anagnostopoulos, Alexia
Unknown Affiliation
Bernasconi, Enos
Unknown Affiliation
Braun, Dominique Laurent
Unknown Affiliation
Bucher, Heíner C.C.
Unknown Affiliation
Calmy, Alexandra
Unknown Affiliation
Cavassini, Matthias
Unknown Affiliation
Ciuffi, Angela
Unknown Affiliation
Dollenmaier, Guenter
Unknown Affiliation
Egger, Matthias
Unknown Affiliation
Elzi, Luigia
Unknown Affiliation
Fehr, Jan Sven
Unknown Affiliation
Fellay, Jacques
Unknown Affiliation
Fux, Christoph Andreas
Unknown Affiliation
Hasse, Barbara Katharina
Unknown Affiliation
Hirsch, Hans H.
Unknown Affiliation
Hoffmann, Matthias
Unknown Affiliation
Huber, Michael J.
Unknown Affiliation
Kaiser, Laurent K.
Unknown Affiliation
Keiser, Olivia
Unknown Affiliation
Klimkait, Thomas
Unknown Affiliation
Kouyos, Roger D.
Unknown Affiliation
Kovari, Helen
Unknown Affiliation
Martinetti, Gladys
Unknown Affiliation
Martinez de Tejada, Begoña
Unknown Affiliation
Marzolini, Catia
Unknown Affiliation
Metzner, Karin Jutta
Unknown Affiliation
Müller, Nicolas J.
Unknown Affiliation
Nemeth, Johannes
Unknown Affiliation
Nicca, Dunja
Unknown Affiliation
Paioni, Paolo
Unknown Affiliation
Pantaleo, Giuseppe P.
Unknown Affiliation
Perreau, Matthieu
Unknown Affiliation
Rauch, Andri
Unknown Affiliation
Schmid, Patrick
Unknown Affiliation
Speck, Roberto F.
Unknown Affiliation
Stöckle, Marcel
Unknown Affiliation
Trkola, Alexandra
Unknown Affiliation
Yerly, Sabine T.B.D.
Unknown Affiliation
Harxhi, Arjan K.
Unknown Affiliation
Losso, Marcelo Horacio
Unknown Affiliation
Zangerle, Robert
Unknown Affiliation
Clumeck, Nathan N.
Unknown Affiliation
de Wit, Stéphane
Unknown Affiliation
Delforge, Marc D.
Unknown Affiliation
Florence, Eric
Unknown Affiliation
Vandekerckhove, Linos P.R.
Unknown Affiliation
Begovac, J.
Unknown Affiliation
Jilich, David
Unknown Affiliation
Kronborg, Gitte
Unknown Affiliation
Benfield, Thomas Lars
Unknown Affiliation
Gerstoft, Jan
Unknown Affiliation
Kirk, Ole
Unknown Affiliation
Pedersen, Court K.
Unknown Affiliation
Johansen, I. S.
Unknown Affiliation
Østergaard, Lars Jørgen
Unknown Affiliation
Wiese, Lothar
Unknown Affiliation
Viard, Jean Paul
Unknown Affiliation
Lacombe, Karine
Unknown Affiliation
Pradier, C.
Unknown Affiliation
Fontas, Éric
Unknown Affiliation
Duvivier, Claudine
Unknown Affiliation
Rockstroh, Jürgen Kurt
Unknown Affiliation
Degen, Olaf
Unknown Affiliation
Hoffmann, Christian
Unknown Affiliation
Stellbrink, Hans Jürgen
Unknown Affiliation
Bogner, Johannes Richard
Unknown Affiliation
Fätkenheuer, Gerd
Unknown Affiliation
Gottfreðsson, Magnús
Unknown Affiliation
Turner, Dan
Unknown Affiliation
Shahar, Eduardo
Unknown Affiliation
Elinav, Hila
Unknown Affiliation
Elbirt, Daniel G.
Unknown Affiliation
d’Arminio-Monforte, Antonella
Unknown Affiliation
Mussini, Cristina
Unknown Affiliation
Gabbuti, Andrea
Unknown Affiliation
Lazzarin, Adriano
Unknown Affiliation
Castagna, Antonella
Unknown Affiliation
Gianotti, Nicola
Unknown Affiliation
Galli, Massimo
Unknown Affiliation
Staub, Thérèse
Unknown Affiliation
Hemmer, Robert J.P.
Unknown Affiliation
van der Valk, Marc
Unknown Affiliation
Bruun, Johann Nikolai
Unknown Affiliation
Ba̧kowska, Elżbieta
Unknown Affiliation
Flisiak, Robert
Unknown Affiliation
Beniowski, Marek
Unknown Affiliation
Mozer-Lisewska, Iwona
Unknown Affiliation
Mansinho, Kamal
Unknown Affiliation
Maltêz, Fernando Manuel
Unknown Affiliation
Radoi, Roxana
Unknown Affiliation
Gusev, Denis А.
Unknown Affiliation
Tomažič, Janez
Unknown Affiliation
Miró, José Mª
Unknown Affiliation
Miró, Josep Ma
Unknown Affiliation
Martínez, Estebán Sampedro
Unknown Affiliation
García, Federico Alcacer
Unknown Affiliation
Blanco, José Luís Munoz
Unknown Affiliation
Mallolas, Josep
Unknown Affiliation
Moreno, Santiago C.
Unknown Affiliation
Clotet, Bonaventura
Unknown Affiliation
Puig, Jordi M.
Unknown Affiliation
Llibre, Josep María
Unknown Affiliation
Domingo, Pere
Unknown Affiliation
Samb́eat, María Antònia
Unknown Affiliation
Thalme, Anders
Unknown Affiliation
Sonnerb̈org, Anders
Unknown Affiliation
Brannstrom, Johanna
Unknown Affiliation
Kusejko, Katharina
Unknown Affiliation
Braun, Dominique L.
Unknown Affiliation
Cavassini, Matthias
Unknown Affiliation
Calmy, Alexandra
Unknown Affiliation
Furrer, Hansjakob Jackob
Unknown Affiliation
Battegay, Manuel
Unknown Affiliation
Schmid, Patrick
Unknown Affiliation
Johnson, Anne M.
Unknown Affiliation
Edwards, Simon G.
Unknown Affiliation
Phillips, Andrew N.
Unknown Affiliation
Johnson, Margaret A.
Unknown Affiliation
Orkin, Chloë M.
Unknown Affiliation
Winston, Alan
Unknown Affiliation
Leen, Clifford L.S.
Unknown Affiliation
Karpov, Igor Alexandrovich
Unknown Affiliation
Lundgren, Jens Dilling
Unknown Affiliation
Aho, Inka
Unknown Affiliation
Pradier, Christian
Unknown Affiliation
Matulionytė, Raimonda
Unknown Affiliation
Oprea, Cristiana
Unknown Affiliation
Kowalska, Justyna Dominika
Unknown Affiliation
Miró, José María ª.
Unknown Affiliation
Guaraldi, Giovanni
Unknown Affiliation
Paredes, Roger
Unknown Affiliation
Larsen, Jakob Friis
Unknown Affiliation
Neesgaard, Bastian
Unknown Affiliation
Jaschinski, Nadine
Unknown Affiliation
Raben, Dorthe
Unknown Affiliation
Kristensen, Dennis Karsten
Unknown Affiliation
Elsing, T. W.
Unknown Affiliation
Ahmed, Aijaz
Unknown Affiliation
Phillips, Andrew N.
Unknown Affiliation
Cozzi-Lepri, Alessandro
Unknown Affiliation
Pelchen-Matthews, Annegret
Unknown Affiliation
Statistics
Citations: 10
Authors: 152
Affiliations: 9
Identifiers
Doi:
10.1111/liv.15519
ISSN:
14783223
Research Areas
Cancer
Environmental
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative