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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Optimization of entrapment of metronidazole in amphiphilic β-cyclodextrin nanospheres
Journal of Pharmaceutical and Biomedical Analysis, Volume 41, No. 3, Year 2006
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Description
Several aspects of the manufacture of nanospheres containing metronidazole were studied. Nanospheres made of amphiphilic β-cyclodextrin containing metronidazole were prepared by adding an acetone solution of amphiphilic cyclodextrin to an aqueous solution of metronidazole with or without Pluronic PE/F68® as the surfactant. An optimized formulation with high encapsulation efficiencies and with an appropriate particle size for intravenous administration, was developed. The entrapment of metronidazole was strongly dependent of the method of preparation and drug concentrations. These nanospheres prepared by nanocrystallization are promising carriers for metronidazole in the treatment of hepatic abscess. © 2006 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Lahiani-Skiba, Malika
France, Rouen
Aden - Nutrition, Inflammation et Dysfonction de L'axe Intestin-cerveau
Bounoure, Frédéric
France, Rouen
Aden - Nutrition, Inflammation et Dysfonction de L'axe Intestin-cerveau
Shawky-Tous, Sozan
Egypt, Asyut
Faculty of Pharmacy
Arnaud, P.
France, Rouen
Aden - Nutrition, Inflammation et Dysfonction de L'axe Intestin-cerveau
Skiba, Mohamed
France, Rouen
Aden - Nutrition, Inflammation et Dysfonction de L'axe Intestin-cerveau
Statistics
Citations: 17
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/j.jpba.2006.01.021
ISSN:
07317085