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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Drug-development concepts as guides for optimizing clinical trials of supplemental zinc for populations at risk of deficiency or diarrhea
Nutrition Reviews, Volume 75, No. 3, Year 2017
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Description
Studies on the efficacy of zinc supplementation for treatment or prevention of diarrhea have shown an inconsistent effect in populations at risk for zinc deficiency. Unlike drugs, which have no preexisting presence in the body, endogenous zinc must be assessed pharmacokinetically by isotope tracer studies. Although such methods have produced much data, very few studies have estimated the dose and the timing of dosing of zinc supplementation. This review examines drug kinetics used to establish the best dose, the timing of such doses, and the mechanism of action through pharmacodynamic markers and applies them, where possible, to zinc supplements. The findings reveal that little is known, especially in children at highest risk of zinc deficiency. Key data missing to inform proper dosing, whether for treatment of disease or for preventive nutrient supplementation, are noted. Addressing these uncertainties could improve study design, leading to future studies of zinc supplements that might be of greater benefit. © The Author(s) 2017. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved.
Authors & Co-Authors
Young, Graeme P.
Australia, Adelaide
The College of Medicine and Public Health
Mortimer, Elissa
Australia, Adelaide
The College of Medicine and Public Health
Gopalsamy, Geetha Lavaniya
Australia, Adelaide
The College of Medicine and Public Health
Australia, Canberra
Commonwealth Scientific and Industrial Research Organisation
Krebs, Nancy F.
United States, Aurora
University of Colorado School of Medicine
Manary, Mark J.
United States, St. Louis
Washington University in St. Louis
Ramakrishna, Balakrishnan S.
India, Kattankulathur
Srm Institute of Science and Technology
Miller, Leland V.
United States, Aurora
University of Colorado School of Medicine
Statistics
Citations: 2
Authors: 7
Affiliations: 7
Identifiers
Doi:
10.1093/nutrit/nuw065
ISSN:
00296643
Research Areas
Maternal And Child Health