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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A randomized trial of chloramphenicol vs. Trimethoprim–sulfamethoxazole for the treatment of malnourished children with community–acquired pneumonia
Pediatric Infectious Disease Journal, Volume 14, No. 11, Year 1995
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Description
Children in developing countries who present with malnutrition often have infections, particularly pneumonia, at the time of presentation. We evaluated the initial antibiotic management of 144 Gambian children who presented for the first time with malnutrition and who had clinical or radiologic evidence of pneumonia. They were enrolled in a double blind trial of trimethoprim-sulfamethoxazole vs. chloramphenicol. Most children in the study underwent detailed investigations of bacterial and viral etiology as part of another study. The study drug was administered for a week along with oral metronidazole, vitamins and standardized nutritional therapy. Treatment failure was defined as the need for change to parenteral antibiotics during treatment, failure to respond to a week of treatment with the study drug or relapse during the following 2 weeks. There were no differences between the treatment groups in the clinical indicators of severity, etiology or radiologic findings. Thirty-three children were excluded from the analysis because of tuberculosis, inappropriate enrollment or inadequate follow-up. Of the 111 children remaining, 32 (16 in each arm of the study) failed treatment. Clinical failure was not related… © 1995 by Williams and Wilkins.
Authors & Co-Authors
Mulholland, Edward Kim
Gambia, Banjul
Medical Research Council Laboratories Gambia
Falade, Adegoke Gbadegesin
Gambia, Banjul
Medical Research Council Laboratories Gambia
Corrah, P. Tumani
Gambia, Banjul
Medical Research Council Laboratories Gambia
Omosigho, Charles
Gambia, Banjul
Medical Research Council Laboratories Gambia
N'Jai, Pamela C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Giadom, Barry
Gambia, Banjul
Medical Research Council Laboratories Gambia
Adegbola, Richard A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Tschäppeler, Heinz
Gambia, Banjul
Medical Research Council Laboratories Gambia
Todd, Jim E.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Greenwood, Brian M.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Statistics
Citations: 24
Authors: 10
Affiliations: 1
Identifiers
Doi:
10.1097/00006454-199511000-00007
ISSN:
08913668
e-ISSN:
15320987
Research Areas
Disability
Food Security
Health System And Policy
Maternal And Child Health
Study Design
Cohort Study