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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Vasorelaxant and anti-platelet aggregation effects of aqueous Ocimum basilicum extract
Journal of Ethnopharmacology, Volume 125, No. 1, Year 2009
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Description
Aim of the study: In this work the endothelium-dependant vasorelaxant and anti-platelet aggregation activities of an aqueous extract from Ocimum basilicum were studied. Materials and methods: The vasorelaxant effect was undertaken in thoracic aorta from three experimental groups of rats: one of them (NCG) fed with standard diet, the second (HCG) with hypercholesterolemic diet (HCD) and the third (BTG) with hypercholesterolemic diet together with an intragastric administration of Ocimum basilicum extract at a dose of 0.5 g/kg body weight for a period of 10 weeks. The in vitro anti-platelet aggregation of Ocimum basilicum extract was studied using thrombin (0.5 U/ml) and ADP (5 μM) as agonists. Results: The results show that the HCD statistically decreases vascular relaxation in HCG compared to NCG (p < 0.001) and increases the vascular responses to phenylephrine (p < 0.02). Ocimum basilicum extract exerts a significant vasorelaxant effect at 10-5 M (p < 0.01) and 10-4 M carbachol (p = 0.001). The plant extract also tends to suppress the elevated contractions induced by HCD (p = 0.05). The extract inhibits ADP-induced platelet aggregation by 13%, 28.2%, 30.5%, 44.7% and 53% at a dose of 1, 2, 3, 4 and 5 g/l, respectively. Thrombin-induced platelet activation was also reduced by 15%, 23%, 40%, 38.4%, and 42% at the same doses of extract described above. Conclusion: The use of Ocimum basilicum as medicinal plant could be beneficial for cardiovascular system. © 2009 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Amrani, S.
Morocco, Oujda
Université Mohammed Premier Oujda
Harnafi, Hicham
Morocco, Oujda
Université Mohammed Premier Oujda
Gadi, Dounia
Morocco, Oujda
Université Mohammed Premier Oujda
Mekhfi, Hassane
Morocco, Oujda
Université Mohammed Premier Oujda
Legssyer, Abdelkhaleq
Morocco, Oujda
Université Mohammed Premier Oujda
Aziz, Mohammed
Morocco, Oujda
Université Mohammed Premier Oujda
Martin-Nizard, Françoise
France, Paris
Inserm
Boscá, Lisardo
Spain, Madrid
Csic-uam - Instituto de Investigaciones Biomédicas Alberto Sols Iibm
Statistics
Citations: 64
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/j.jep.2009.05.043
ISSN:
03788741
Research Areas
Noncommunicable Diseases