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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Transmitted HIV type 1 drug resistance among individuals with recent HIV infection in east and southern Africa
AIDS Research and Human Retroviruses, Volume 27, No. 1, Year 2011
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Description
To characterize WHO-defined transmitted HIV drug resistance mutation (TDRM) data from recently HIV-infected African volunteers, we sequenced HIV (pol) and evaluated for TDRM the earliest available specimens from ARV-naive volunteers diagnosed within 1 year of their estimated date of infection at eight research centers in sub-Saharan Africa. TDRMs were detected in 19/408 (5%) volunteers. The prevalence of TDRMs varied by research center, from 5/26 (19%) in Entebbe, 6/78 (8%) in Kigali, 2/49 (4%) in Kilifi, to 3/106 (3%) in Lusaka. One of five volunteers from Cape Town (20%) had TDRMs. Despite small numbers, our data suggest an increase in DRMs by year of infection in Zambia (p = 0.004). The prevalence observed in Entebbe was high across the entire study. ARV history data from 12 (63%) HIV-infected sexual partners were available; 3 reported ARV use prior to transmission. Among four partners with sequence data available, transmission linkage was confirmed and two had the same TDRMs as the newly infected volunteer (both K103N). As ARV therapy continues to increase in availability throughout Africa, monitoring incident virus strains for the presence of TDRMs should be a priority. Early HIV infection cohorts provide an excellent and important platform to monitor the development of TDRMs to inform treatment guidelines, drug choices, and strategies for secondary prevention of TDRM transmission. © Copyright 2011, Mary Ann Liebert, Inc.
Authors & Co-Authors
Price, Matt A.
United States, San Francisco
Ucsf Center for Aids Prevention Studies
United States, New York
International Aids Vaccine Initiative
Wallis, Carole Lorraine
South Africa, Johannesburg
University of the Witwatersrand
Lakhi, Shabir
Zambia, Lusaka
Rwanda Zambia Hiv Research Group
Zambia, Ndola
Rwanda Zambia Hiv Research Group
Rwanda, Kigali
Rwanda Zambia Hiv Research Group
Karita, Etienne
Zambia, Lusaka
Rwanda Zambia Hiv Research Group
Zambia, Ndola
Rwanda Zambia Hiv Research Group
Rwanda, Kigali
Rwanda Zambia Hiv Research Group
Kamali, Anatoli
United Kingdom, London
Medical Research Council
Anzala, Aggrey Omu
Kenya, Nairobi
Kenya Aids Vaccine Initiative
Sanders, Eduard Joachim
Kenya, Nairobi
Kenya Medical Research Institute
United Kingdom, Oxford
University of Oxford
Bekker, Linda-Gail Gail
South Africa, Cape Town
Desmond Tutu Health Foundation
Twesigye, Rogers
United Kingdom, London
Medical Research Council
Hunter, Eric
Zambia, Lusaka
Rwanda Zambia Hiv Research Group
Zambia, Ndola
Rwanda Zambia Hiv Research Group
Rwanda, Kigali
Rwanda Zambia Hiv Research Group
United States, Atlanta
Emory University
Kaleebu, Pontiano P.
United States, San Francisco
Ucsf Center for Aids Prevention Studies
United States, New York
International Aids Vaccine Initiative
United Kingdom, London
Medical Research Council
Kayitenkore, Kayitesi
Zambia, Lusaka
Rwanda Zambia Hiv Research Group
Zambia, Ndola
Rwanda Zambia Hiv Research Group
Rwanda, Kigali
Rwanda Zambia Hiv Research Group
Allen, Susan A.
Zambia, Lusaka
Rwanda Zambia Hiv Research Group
Zambia, Ndola
Rwanda Zambia Hiv Research Group
Rwanda, Kigali
Rwanda Zambia Hiv Research Group
United States, Atlanta
Rollins School of Public Health
Ruzagira, Eugene
United Kingdom, London
Medical Research Council
Mwangome, Mary N.
Kenya, Nairobi
Kenya Medical Research Institute
Mutua, Gaudensia Nzembi
Kenya, Nairobi
Kenya Aids Vaccine Initiative
Amornkul, Pauli N.
United States, San Francisco
Ucsf Center for Aids Prevention Studies
United States, New York
International Aids Vaccine Initiative
Stevens, Gwynn
United States, San Francisco
Ucsf Center for Aids Prevention Studies
United States, New York
International Aids Vaccine Initiative
Pond, Sergei L.Kosakovsky
United States, La Jolla
University of California, San Diego
Schaefer, Malinda R.
United States, Atlanta
Emory University
Papathanasopoulos, Maria
South Africa, Johannesburg
University of the Witwatersrand
Stevens, Wendy Susan
South Africa, Johannesburg
University of the Witwatersrand
Gilmour, Jill W.
United States, San Francisco
Ucsf Center for Aids Prevention Studies
United States, New York
International Aids Vaccine Initiative
Statistics
Citations: 130
Authors: 23
Affiliations: 14
Identifiers
Doi:
10.1089/aid.2010.0030
ISSN:
08892229
Research Areas
Cancer
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Zambia