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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Impairment of alternative macrophage activation delays cutaneous leishmaniasis in nonhealing BALB/c mice
Journal of Immunology, Volume 176, No. 2, Year 2006
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Description
Expressed on various cell types, the IL-4Rα is a component of both receptors for IL-4 and IL-13. Susceptibility of BALB/c mice to Leishmania major is believed to be dependent on the development of IL-4- and IL-13-producing Th2 cells, while IFN-γ secretion by Th1 cells is related to resistance. Despite a sustained development of Th2 cells, IL-4Rα-deficient BALB/c mice are able to control acute cutaneous leishmaniasis, suggesting that IL-4Rα-bearing cells other than Th2 cells contribute to susceptibility. To analyze the contribution of the IL-4Rα on macrophages, recently generated macrophage/neutrophil-specific IL-4Rα-deficient mice on a susceptible BALB/c genetic background were infected with L. major. Strikingly, macrophage/neutrophil-specific IL-4Rα-deficient mice showed a significantly delayed disease progression with normal Th2 and type 2 Ab responses but improved macrophage leishmanicidal effector functions and reduced arginase activity. Together, these results suggest that alternative macrophage activation contributes to susceptibility in cutaneous leishmaniasis. Copyright © 2006 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Hólscher, Christoph
South Africa, Cape Town
University of Cape Town
Germany, Borstel
Forschungszentrum Borstel - Zentrum Für Medizin Und Biowissenschaften
Arendse, Berenice
South Africa, Cape Town
University of Cape Town
Schwegmann, Anita
South Africa, Cape Town
University of Cape Town
Myburgh, Elmarie
South Africa, Cape Town
University of Cape Town
Brombacher, Frank
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 124
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.4049/jimmunol.176.2.1115
ISSN:
00221767
Research Areas
Genetics And Genomics