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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A web platform for the network analysis of high-throughput data in melanoma and its use to investigate mechanisms of resistance to anti-PD1 immunotherapy
Biochimica et Biophysica Acta - Molecular Basis of Disease, Volume 1864, No. 6, Year 2018
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Description
Cellular phenotypes are established and controlled by complex and precisely orchestrated molecular networks. In cancer, mutations and dysregulations of multiple molecular factors perturb the regulation of these networks and lead to malignant transformation. High-throughput technologies are a valuable source of information to establish the complex molecular relationships behind the emergence of malignancy, but full exploitation of this massive amount of data requires bioinformatics tools that rely on network-based analyses. In this report we present the Virtual Melanoma Cell, an online tool developed to facilitate the mining and interpretation of high-throughput data on melanoma by biomedical researches. The platform is based on a comprehensive, manually generated and expert-validated regulatory map composed of signaling pathways important in malignant melanoma. The Virtual Melanoma Cell is a tool designed to accept, visualize and analyze user-generated datasets. It is available at: https://www.vcells.net/melanoma. To illustrate the utilization of the web platform and the regulatory map, we have analyzed a large publicly available dataset accounting for anti-PD1 immunotherapy treatment of malignant melanoma patients. © 2018 Elsevier B.V.
Authors & Co-Authors
Eberhardt, Martin
Unknown Affiliation
Gupta, Shailendra Kumar
Unknown Affiliation
Khan, Faiz Muhammad
Unknown Affiliation
Wolkenhauer, Olaf
Unknown Affiliation
Pützer, Brigitte M.
Unknown Affiliation
Vera, Julio
Unknown Affiliation
Statistics
Citations: 17
Authors: 6
Identifiers
Doi:
10.1016/j.bbadis.2018.01.020
ISSN:
09254439
Research Areas
Cancer
Environmental