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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A novel approach to identifying a neuroimaging biomarker for patients with serious mental illness
Journal of Neuropsychiatry and Clinical Neurosciences, Volume 29, No. 3, Year 2017
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Description
Serious mental illness (SMI) is disabling, and current interventions are ineffective for many. This exploratory study sought to demonstrate the feasibility of applying topological data analysis (TDA) to resting-state functional connectivity data obtained from a heterogeneous sample of 235 adult inpatients to identify a biomarker of treatment response. TDA identified two groups based on connectivity between the prefrontal cortex and striatal regions: patients admitted with greater functional connectivity between these regions evidenced less improvement from admission to discharge than patients with lesser connectivity between them. TDA identified a potential biomarker of an attenuated treatment response among inpatients with SMI. Insofar as the observed pattern of resting-state functional connectivity collected early during treatment is replicable, this potential biomarker may indicate the need to modify standard of care for a small, albeit meaningful, percentage of patients. © 2017, American Psychiatric Association. All rights reserved.
Authors & Co-Authors
Salas, Ramiro
United States, Houston
Baylor College of Medicine
Sharp, Carla
United States, Houston
The Menninger Clinic
United States, Houston
University of Houston
Statistics
Citations: 15
Authors: 2
Affiliations: 4
Identifiers
Doi:
10.1176/appi.neuropsych.16090174
ISSN:
08950172
Research Areas
Mental Health
Study Design
Exploratory Study