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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa
Journal of Ethnopharmacology, Volume 92, No. 2-3, Year 2004
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Description
The increasing prevalence and distribution of malaria has been attributed to a number of factors, one of them being the emergence and spread of drug resistant parasites. Efforts are now being directed towards the discovery and development of new chemically diverse antimalarial agents. The present study reports on the in vitro antiplasmodial activity of 134 plant taxa native to or naturalised in South Africa, representing 54 families, which were selected semi-quantitatively using weighted criteria. The plant extracts were tested for in vitro activity against a Plasmodium falciparum strain D10 using the parasite lactate dehydrogenase (pLDH) assay. Of the 134 species assayed, 49% showed promising antiplasmodial activity (IC50≤10 μg/ml), while 17% were found to be highly active (IC50≤5 μg/ml). Several plant species and genera were shown for the first time to possess in vitro antiplasmodial activity. These results support a rational rather than random approach to the selection of antiplasmodial screening candidates, and identify a number of promising taxa for further investigation as plant-based antimalarial agents. © 2004 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Clarkson, Cailean
South Africa, Cape Town
University of Cape Town
Maharaj, Vinesh Jaichand
South Africa, Pretoria
The Council for Scientific and Industrial Research
Crouch, Neil R.
South Africa, Pretoria
South African National Biodiversity Institute
South Africa, Durban
University of Kwazulu-natal
Grace, Olwen M.
South Africa, Pretoria
South African National Biodiversity Institute
Pillay, Pamisha
South Africa, Pretoria
The Council for Scientific and Industrial Research
Matsabisa, Motlalepula Gilbert
South Africa, Tygerberg
South African Medical Research Council
Bhagwandin, Niresh
South Africa, Tygerberg
South African Medical Research Council
Smith, Peter J.D.
South Africa, Cape Town
University of Cape Town
Folb, Peter I.
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 538
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1016/j.jep.2004.02.011
ISSN:
03788741
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
South Africa