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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Cerebrospinal fluid myelin basic protein as a prognostic biomarker in dogs with thoracolumbar intervertebral disk herniation
Journal of Veterinary Internal Medicine, Volume 24, No. 4, Year 2010
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Description
Background: Release of myelin basic protein (MBP) into the cerebrospinal fluid (CSF) is associated with active demyelination and correlates with outcome in various neurological diseases. Hypothesis/Objectives: To describe associations among CSF MBP concentration, initial neurological dysfunction, and long-term ambulatory outcome in dogs with acute thoracolumbar intervertebral disk herniation (IVDH). Animals: Five hundred and seventy-four dogs with acute thoracolumbar IVDH and 16 clinically normal dogs. Methods: Prospective case series clinical study. Signalment, initial neurological dysfunction as determined by a modified Frankel score (MFS), and ambulatory outcome at > 3-month follow-up were recorded. Cisternal CSF MBP concentration was determined by an ELISA. Associations were estimated between CSF MBP concentration and various clinical parameters. Results: Dogs with thoracolumbar IVDH that did not ambulate at follow-up had a higher CSF MBP concentration (median, 3.56 ng/mL; range, 0.59-51.2 ng/mL) compared with control dogs (median, 2.22 ng/mL; range, 0-3.82 ng/mL) (P = .032). A CSF MBP concentration of ≥3 ng/mL had a sensitivity of 78% and specificity of 76% to predict an unsuccessful outcome based on receiver-operating characteristics curve analysis (area under the curve = 0.688, P = .079). Affected dogs with A CSF MBP concentration ≥ 3 ng/mL had 0.09 times the odds of ambulation at follow-up compared with affected dogs with CSF MBP concentration <3 ng/mL when adjusted for initial MFS (95% confidence interval 0.01-0.66, P = .018). Conclusions and Clinical Importance: These results would suggest that CSF MBP concentration may be useful as an independent prognostic indicator in dogs with thoracolumbar IVDH. © 2010 by the American College of Veterinary Internal Medicine.
Authors & Co-Authors
Levine, Gwendolyn J.
Unknown Affiliation
Levine, Jonathan M.
Unknown Affiliation
Witsberger, T. H.
Unknown Affiliation
Kerwin, Sharon C.
Unknown Affiliation
Russell, K. E.
Unknown Affiliation
Suchodolski, Jan S.
Unknown Affiliation
Steiner, Jörg Manfred
Unknown Affiliation
Fosgate, Geoffrey T.
Unknown Affiliation
Statistics
Citations: 42
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1111/j.1939-1676.2010.0531.x
e-ISSN:
19391676
Research Areas
Health System And Policy
Study Design
Cohort Study