Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Antioxidant status and circulating lipids are altered in human gestational diabetes and macrosomia
Translational Research, Volume 150, No. 3, Year 2007
Notification
URL copied to clipboard!
Description
Fetuses from mothers with gestational diabetes are at increased risk of developing neonatal macrosomia and oxidative stress. We investigated the modulation of antioxidant status and circulating lipids in gestational diabetic mothers and their macrosomic babies and in healthy age-matched pregnant women and their newborns. The serum antioxidant status was assessed by employing anti-radical resistance kit (KRL; Kirial International SA, Couternon, France) and determining levels of vitamin A, C, and E and the activity of superoxide dismutase (SOD). Circulating serum lipids were quantified, and lipid peroxidation was measured as the concentrations of serum thiobarbituric acid-reactive substances (TBARS). As compared with non-diabetic mothers, gestational diabetic women exhibited decreased levels of vitamin E and enhanced concentrations of vitamin C without any changes in vitamin A. Vitamin A and C levels did not change in macrosomic babies except vitamin E whose levels were lower in these infants than in the newborns of non-diabetic mothers. Gestational diabetes mellitus (GDM) and macrosomia were also associated with impaired SOD activities and enhanced TBARS levels. Globally, total serum antioxidant defense status in diabetic mothers and their macrosomic babies was diminished as compared with control subjects. Triglyceride and cholesterol concentrations did not differ significantly between gestational diabetic and control mothers; however, macrosomia was associated with enhanced plasma cholesterol and triglyceride levels. These results suggest that human GDM and macrosomia are associated with downregulation of antioxidant status, and macrosomic infants also exhibit altered lipid metabolism. © 2007 Mosby, Inc. All rights reserved.
Authors & Co-Authors
Grissa, Oussama
Tunisia, Sousse
Hopital Farhat Hached Sousse
Atègbo, Jean Marc
France, Dijon
Université de Bourgogne
Benin, Cotonou
University of Abomey-calavi
Yessoufou, Akadiri
France, Dijon
Université de Bourgogne
Benin, Cotonou
University of Abomey-calavi
Tabka, Zouhaïr
Tunisia, Sousse
Hopital Farhat Hached Sousse
Miled, Abdelhédi
Tunisia, Sousse
Hopital Farhat Hached Sousse
Jerbi, Mehdi
Tunisia, Sousse
Hopital Farhat Hached Sousse
Dramane, Karim L.
Benin, Cotonou
University of Abomey-calavi
Moutairou, Kabirou A.
Benin, Cotonou
University of Abomey-calavi
Prost, Josiane L.
France, Dijon
Université de Bourgogne
Hichami, Aziz
France, Dijon
Université de Bourgogne
Khan, Naim Akhtar
France, Dijon
Université de Bourgogne
Statistics
Citations: 107
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.1016/j.trsl.2007.03.007
ISSN:
19315244
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Participants Gender
Female