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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Epidemiology of hookworm infection in Kintampo North Municipality, Ghana: Patterns of malaria coinfection, anemia, and albendazole treatment failure
American Journal of Tropical Medicine and Hygiene, Volume 84, No. 5, Year 2011
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Description
A cross-sectional pilot study of hookworm infection was carried out among 292 subjects from 62 households in Kintampo North, Ghana. The overall prevalence of hookworm infection was 45%, peaking in those 11-20 years old (58.5%). In children, risk factors for hookworm infection included coinfection with malaria and increased serum immunoglobulin G reactivity to hookworm secretory antigens. Risk factors for infection in adults included poor nutritional status, not using a latrine, not wearing shoes, and occupation (farming). Although albendazole therapy was associated with an overall egg reduction rate of 82%, 37 subjects (39%) remained infected. Among those who failed therapy, treatment was not associated with a significant reduction in egg excretion, and nearly one-third had higher counts on repeat examination. These data confirm a high prevalence of low-intensity hookworm infection in central Ghana and its association with poor nutritional status. The high rate of albendazole failure raises concern about emerging resistance. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Humphries, Debbie L.
United States, New Haven
Yale University
Mosites, Emily M.
United States, Nashville
Tennessee Department of Health
Otchere, Joseph
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Twum, Welbeck Amoani
Ghana, Accra
Ministry of Health Ghana
Woo, Lauren
United States, New Haven
Yale School of Medicine
Jones-Sanpei, Hinckley
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Harrison, Lisa M.
United States, New Haven
Yale School of Medicine
Bungiro, Richard D.
Unknown Affiliation
Benham-Pyle, Blair
United States, New Haven
Yale School of Medicine
Bimi, Langbong
Ghana, Accra
University of Ghana
Edoh, Dominic Adotei
Ghana, Accra
University of Ghana
Bosompem, Kwabena Mante
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Wilson, Michael David
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Cappello, Michael
United States, New Haven
Yale School of Medicine
Statistics
Citations: 117
Authors: 14
Affiliations: 7
Identifiers
Doi:
10.4269/ajtmh.2011.11-0003
ISSN:
00029637
Research Areas
Environmental
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Ghana