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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Association study of the trinucleotide repeat polymorphism within SMARCA2 and schizophrenia
BMC Genetics, Volume 7, Article 34, Year 2006
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Description
Background: Brahma (BRM) is a key component of the multisubunit SWI/SNF complex, a complex which uses the energy of ATP hydrolysis to remodel chromatin. BRM contains an N-terminal polyglutamine domain, encoded by a polymorphic trinucleotide (CAA/CAG) repeat, the only known polymorphism in the coding region of the gene (SMARCA2). We have examined the association of this polymorphism with schizophrenia in a family-based and case/control study. SMARCA2 was chosen as a candidate gene because of its specific role in developmental pathways, its high expression level in the brain and some evidence of its association with schizophrenia spectrum disorder from genome-wide linkage analysis. Results: Family-based analysis with 281 complete and incomplete triads showed that there is no significant preferential transmission of any of the alleles to the affected offspring. Also, in the case/control analysis, similar allele and genotype distributions were observed between affected cases (n = 289) and unaffected controls (n = 273) in each of three Caucasian populations studied: French Canadian, Tunisian and other Caucasians of European origin. Conclusion: Results from our f amily-based and case-control association study suggest that there is no association between the trinucleotide repeat polymorphism within SMARCA2 and schizophrenia. © 2006 Sengupta et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Sengupta, Sarojini M.
Canada, Montreal
Université Mcgill
Canada, Montreal
Le Centre de Recherche Douglas
Xiong, Lan
Canada, Montreal
Université Mcgill
Canada, Montreal
Hôpital Notre-dame
Fathalli, Ferid
Canada, Montreal
Le Centre de Recherche Douglas
Canada, Montreal
Hôpital Notre-dame
Benkelfat, Chawki
Canada, Montreal
Université Mcgill
Tabbane, Karim
Tunisia, Tunis
Université de Tunis
Danics, Zoltán
Hungary, Budapest
National Institute of Psychiatry and Neurology
Labelle, Alain
Canada, Ottawa
University of Ottawa
Lal, Samarthji
Canada, Montreal
Le Centre de Recherche Douglas
Canada, Montreal
Université Mcgill
Krebs, Marie Odile
France, Paris
Centre Hospitalier Sainte-anne
Rouleau, Guy Armand
Canada, Montreal
Hôpital Notre-dame
Joober, Ridha
Canada, Montreal
Université Mcgill
Canada, Montreal
Le Centre de Recherche Douglas
Statistics
Citations: 11
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1186/1471-2156-7-34
e-ISSN:
14712156
Research Areas
Genetics And Genomics
Mental Health
Study Design
Case-Control Study