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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Phylogenetic analysis of new hepatitis B virus isolates from Nigeria supports endemicity of genotype E in West Africa
Journal of Medical Virology, Volume 65, No. 3, Year 2001
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Description
Isolates of hepatitis B viruses were collected from 20 acute and chronic hepatitis patients in a highly endemic region of Nigeria. Sequencing classified the isolates to the ayw4, as they all contained the amino acid variations characteristic for that serotype. In the pre-S2 region of five isolates, three to seven amino acids were deleted, suggesting that immune escape mutations previously associated only with chronic HBV infection may be observed also in acute disease. Phylogenetic analysis of the complete pre-S2/S (large S) genes (831 nt) demonstrated that all the viruses belonged to the same genotype E. So far, no isolates of genotype E have been found in any other region of the world, including the Americas. This may suggest a relatively recent introduction of this genotype into humans and would explain the relatively low genetic diversity of viruses belonging to this genotype. One genotype E virus had been found previously in a chimpanzee, and viruses belonging to the CHIMP genotype are related to other genotype E viruses. These findings are compatible with a transmission of genotype E viruses from chimpanzees to humans. © 2001 Wiley-Liss, Inc.
Authors & Co-Authors
Odemuyiwa, Solomon Olawole (Wole)
Luxembourg, Luxembourg
Laboratoire Nationale de Santé Lns
Mulders, Mick Norman
Luxembourg, Luxembourg
Laboratoire Nationale de Santé Lns
Oyedele, Oluseyi I.
Nigeria, Ibadan
University of Ibadan
Ola, Samuel Olawale
Nigeria, Ibadan
University College Hospital, Ibadan
Odaibo, Georgina Njideka
Nigeria, Ibadan
University of Ibadan
Olaleye, David Olufemi
Luxembourg, Luxembourg
Laboratoire Nationale de Santé Lns
Muller, Claude P.
Luxembourg, Luxembourg
Laboratoire Nationale de Santé Lns
Statistics
Citations: 114
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1002/jmv.2058
ISSN:
01466615
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Multi-countries
Nigeria