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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The Magpie Trial: A randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for children at 18 months
BJOG: An International Journal of Obstetrics and Gynaecology, Volume 114, No. 3, Year 2007
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Description
Objective: To assess the long-term effects of in utero exposure to magnesium sulphate for children whose mothers had pre-eclampsia. Design: Assessment at 18 months of age for children whose mothers were recruited to the Magpie Trial (recruitment 1998-2001 ISRCTN 86938761), which compared magnesium sulphate with placebo. Setting: Follow-up of children born at 125 centres in 19 countries across five continents. Population: A total of 6922 children were born to women randomised before delivery at follow-up centres. Of these, 2271 were not included for logistic reasons and 168 were excluded (101 at a centre where <20% were contacted, 40 whose death or disability was due to a problem at conception or embryogenesis and 27 whose parent/s opted out). Therefore, 4483 children were included in follow-up, of whom 3283 (73%) were contacted. Methods: Assessment by questionnaire, with interview and neurodevelopmental testing of selected children. Main outcome measures: Death or neurosensory disability at age of 18 months. Results: Of those allocated magnesium sulphate, 245/1635 (15.0%) were dead or had neurosensory disability at 18 months compared with 233/1648 (14.1%) allocated placebo (relative risk [RR] 1.06, 95% CI 0.90-1.25), and of survivors, 19/1409 (1.3%) had neurosensory disability at 18 months compared with 27/1442 (1.9%) (RR 0.72, 95% CI 0.40-1.29). There were no substantial differences in causes of death or in the risk of individual impairments or disabilities. Conclusions: The lower risk of eclampsia following prophylaxis with magnesium sulphate was not associated with a clear difference in the risk of death or disability for children at 18 months. © RCOG 2006 BJOG An International Journal of Obstetrics and Gynaecology.
Authors & Co-Authors
Duley, Lelia M.M.
United Kingdom, Oxford
Nuffield Department of Medicine
Farrell, Barbara
Unknown Affiliation
Spark, Patsy
Unknown Affiliation
Altman, Douglas G.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Yu, Ly Mee
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Abalos, Edgardo J.
Unknown Affiliation
Carroli, Berenise
Unknown Affiliation
Giordano, Daniel
Unknown Affiliation
Clarke, Michael J.
Unknown Affiliation
Gray, Alastair M.
Unknown Affiliation
Neilson, James P.
Unknown Affiliation
Simon, Judit
Unknown Affiliation
Collins, Rory
Unknown Affiliation
Lilford, Richard J.
Unknown Affiliation
Moodley, Jagdisea M.
Unknown Affiliation
Robson, Stephen Courtenay
Unknown Affiliation
Roberts, Ian G.
Unknown Affiliation
Thornton, Jim G.
Unknown Affiliation
Villar, Josè
Unknown Affiliation
Karolinski, Ariel
Argentina, Buenos Aires
Hospital General de Agudos Carlos G. Durand
Carroli, Guillermo
Unknown Affiliation
Krupitzky, Sara
Argentina, Buenos Aires
Hospital Nacional Professor Dr. Alejandro Posadas
Palermo, Mario S.F.
Argentina, Buenos Aires
Hospital Nacional Professor Dr. Alejandro Posadas
Wilson, Matthew Joseph A.
Australia, Brisbane
Royal Brisbane and Women's Hospital
Crowther, Caroline A.
Australia, Adelaide
Women's and Children's Hospital Adelaide
Shahidullah, Mohammod M.
Bangladesh, Dhaka
Bangabandhu Sheikh Mujib Medical University
Freire, Sálvio
Brazil, Recife
Universidade Federal de Pernambuco
Cobo, Erik
Colombia, Cali
Fundación Valle Del Lili
Gaitán, Hernando G.
Colombia, Bogota
Universidad Nacional de Colombia
Farnot, Ubaldo
Cuba, Havana
Hospital Clinico Quirurgico Hermanos Ameijeiras
Rojas, Georgina
Cuba, Havana
Hospital Clinico Quirurgico Hermanos Ameijeiras
Al-Hussaini, Tarek Khalaf
Egypt, Asyut
Assiut University
Hammad, Emad E.M.
Egypt, Asyut
Assiut University
Danso, Kwabena Asimeng
Ghana, Kumasi
Komfo Anokye Teaching Hospital
Udani, Rekha H.
Unknown Affiliation
Ramji, Siddharth
India, New Delhi
Maulana Azad Medical College
Lema, Valentino Manase
Malawi, Blantyre
Queen Elizabeth Central Hospital Malawi
Tadesse, E.
Malawi, Blantyre
Queen Elizabeth Central Hospital Malawi
Dada, Olukayode A.
Nigeria, Sagamu
Centre for Research in Reproductive Health
Runsewe-Abiodun, Tamrat I.
Nigeria, Ago-iwoye
Olabisi Onabanjo University
Adewole, Isaac Folorunso A.
Nigeria, Ibadan
University College Hospital, Ibadan
Oladokun, Regina Eziuka
Nigeria, Ibadan
University College Hospital, Ibadan
Inimgba, Nestor M.
Nigeria, Port Harcourt
University of Port Harcourt
John, C. T.
Nigeria, Port Harcourt
University of Port Harcourt
Ogu, Rosemary N.
Nigeria, Port Harcourt
University of Port Harcourt
Ekele, Bissallah Ahmed
Nigeria, Sokoto
Usmanu Danfodiyo University
Isah, Ahmed Rufai
Nigeria, Sokoto
Usmanu Danfodiyo University
Onankpa, Ben O.
Nigeria, Sokoto
Usmanu Danfodiyo University
Gul, Fouzia
Pakistan, Peshawar
Lady Reading Hospital
Rajadurai, Victor Samuel
Singapore, Singapore City
Kk Women's and Children's Hospital
Pirani, N. E.
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Delport, Suzanne D.
South Africa, Pretoria
Kalafong Hospital
Macdonald, A. Peter
South Africa, Pretoria
Kalafong Hospital
Pattinson, Robert Clive
South Africa, Pretoria
Kalafong Hospital
Adhikari, Mirriam A.
South Africa, Congella
King Edward Viii Hospital
Kirsten, Gerhardus Francois
South Africa, Tygerberg
Tygerberg Hospital
Steyn, Daniël Wilhelm
South Africa, Tygerberg
Tygerberg Hospital
van Zyl, Jeanetta I.
South Africa, Tygerberg
Tygerberg Hospital
Statistics
Citations: 139
Authors: 58
Affiliations: 34
Identifiers
Doi:
10.1111/j.1471-0528.2006.01165.x
ISSN:
14700328
Research Areas
Disability
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Female