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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Epstein-Barr virus markers in a series of Burkitt's lymphomas from the West Nile District, Uganda
European Journal of Cancer and Clinical Oncology, Volume 19, No. 10, Year 1983
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Description
In an epidemiological survey in the West Nile District of Uganda, 70 pathologically confirmed BL cases were detected over a 5-yr period; this corresponded to an annual incidence rate of 1.6 per 100,000 general population or about 5 per 100,000 children in the age group 5-14 yr. Of the confirmed cases which were examined by EBV/DNA molecular hybridization, 96% were found to contain an average of 38 EBV genome equivalents per tumour cell, whereas none of the examined unconfirmed cases did. Duplicate hybridization assays in two laboratories were in close agreement. Serological testing showed that 91% of the confirmed BL cases had elevated EBV/VCA titres (≥160) and 64% were EA(D)-positive (≥10). Most of the cases with high EBV/genome content had high VCA titres, but there was a poor correlation between the two parameters among all cases. This study confirms that in high BL incidence areas the association between EBV and this lymphoma is almost constant, whereas it is exceptional in low-incidence areas. This further supports the aetiological implication of EBV in the endemicity of this tumor in equatorial Africa. © 1983.
Authors & Co-Authors
Geser, Anton G.
France, Lyon
Centre International de Recherche Sur le Cancer
Lenoir, G. M.
France, Lyon
Centre International de Recherche Sur le Cancer
Anvret, M.
Sweden, Gothenburg
Göteborgs Universitet
Sweden, Stockholm
Karolinska Institutet
Bornkamm, Georg Wilhelm
Germany, Freiburg Im Breisgau
Universität Freiburg
Klein, George
Sweden, Stockholm
Karolinska Institutet
Williams, Edward H.
Uganda, Nile
Kuluva Hospital
Wright, Dennis Howard
United Kingdom, Southampton
University of Southampton
De-Thé, Guy B.
France, Lyon
Centre International de Recherche Sur le Cancer
Statistics
Citations: 39
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1016/0277-5379(93)90009-T
ISSN:
02775379
Research Areas
Cancer
Genetics And Genomics
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Uganda