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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cross-clade CD8
+
T-cell responses with a preference for the predominant circulating clade
Journal of Acquired Immune Deficiency Syndromes, Volume 40, No. 3, Year 2005
Notification
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Description
Human immunodeficiency virus (HIV) genetic diversity is a major impediment to the design of a successful vaccine. Even if an HIV vaccine is proven effective, it remains to be seen whether this protection will extend to inter-clade, intra-clade, and recombinant strains. We used recombinant vaccinia-based interferon gamma (IFN-©) Elispot assays to test the inter-clade crossreactivity of clades A, B, C, and D HIV Env in two cohorts of HIV-infected Kenyans. Despite the tremendous diversity in this HIV protein, a substantial proportion of multi-clade responses were observed. Although these multi-clade responses correlated well with each other in regression analyses, clade A responses were seen at a higher frequency and at greater relative magnitudes in a proportion of these patients, when compared to the other three clades. Epitope mapping indicates CD8+ T cell recognition of conserved regions of Env, accounting for the high degree of cross-reactivity but not the clade A preference. A better understanding of cross-clade CD8 + T cell responses to HIV may help to predict whether a successful vaccine could be used to stop geographically and genetically distinct HIV epidemics. Copyright © 2005 by Lippincott Williams & Wilkins.
Authors & Co-Authors
McKinnon, Lyle R.
Canada, Winnipeg
University of Manitoba
Ball, Terry Blake
Canada, Winnipeg
University of Manitoba
Kimani, Joshua
Kenya, Nairobi
University of Nairobi
Wachihi, Charles
Kenya, Nairobi
University of Nairobi
Matu, Lucy
Kenya, Nairobi
University of Nairobi
Luo, Ma
Canada, Winnipeg
University of Manitoba
Embreé, Joanne E.
Canada, Winnipeg
University of Manitoba
Fowke, Keith Raymond
Canada, Winnipeg
University of Manitoba
Plummer, Francis Allan
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
Canada, Winnipeg
National Microbiology Laboratory
Statistics
Citations: 38
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1097/01.qai.0000184858.16447.04
ISSN:
15254135
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cohort Study