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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
A54T polymorphism in the fatty acid binding protein 2 studies in a Saudi population with type 2 diabetes mellitus
Lipids in Health and Disease, Volume 13, No. 1, Article 61, Year 2014
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Description
Background: Fatty acid-binding protein 2 (FABP2) is an intracellular protein expressed exclusively in the enterocytes of proximal small intestine. FABP2 has a high affinity for saturated and unsaturated long-chain fatty acids and is believed to be involved in the absorption and transport of dietary fatty acids. Methods. This is a case-control study conceded in 438 T2DM cases and 460 subjects with normal glucose levels and non-obese considered as healthy controls. Allelic discrimination was performed using TaqMan single-nucleotide polymorphism was carried out by real time-polymerase chain reaction (RT-PCR) assays using purified DNA. Results: Clinical data and anthropometric measurements except age, glucose levels and lipid profile of the patients were significantly different from those of the controls (p < 0.05). Statistical analyses failed to show any type of significant association of the polymorphism between cases and controls. However logistic regression analyses was suggests that the TT genotype is significantly associated with male patients (p = 0.001). None of the allele or genotypes of FABP2 A54T was associated with T2DM cases versus the controls (AT genotype, OR = 0.85 (0.64-1.12), p = 0.25; TT genotype, OR = 0.66 (0.39-1.11), p = 0.11; T allele, 0.82 (0.67-1.02), p = 0.08). Conclusion: In conclusion, this study suggests that the above named variant in FABP2 gene is not potential contributor to the risk of T2DM and related traits in a Saudi population. However TT genotype is a risk factor for the disease in males. © 2014 Alharbi et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Alharbi, Khalid Khalaf
Saudi Arabia, Riyadh
College of Applied Medical Sciences
Khan, Imran Ali
Saudi Arabia, Riyadh
College of Applied Medical Sciences
Bazzi, Mohammad Daoud
Saudi Arabia, Riyadh
College of Sciences
Al-Daghri, N. Mohammad
Saudi Arabia, Riyadh
College of Sciences
Hasan, Tarique N.
Saudi Arabia, Riyadh
King Saud University
Alnbaheen, May Salem
Saudi Arabia, Riyadh
King Khalid University Hospital
Saudi Arabia, Riyadh
Saudi Electronic University
Alharbi, Fawiziah Khalaf
Saudi Arabia, Buraidah
Al Qassim University
Al-Sheikh, Yazeed A.
Saudi Arabia, Riyadh
College of Applied Medical Sciences
Syed, Rabbani
Saudi Arabia, Riyadh
College of Applied Medical Sciences
Aboul-Soud, Mourad A.M.
Saudi Arabia, Riyadh
College of Applied Medical Sciences
Statistics
Citations: 10
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1186/1476-511X-13-61
e-ISSN:
1476511X
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Case-Control Study
Participants Gender
Male