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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Reduced ability of newborns to produce CCL3 is associated with increased susceptibility to perinatal human immunodeficiency virus 1 transmission
Journal of General Virology, Volume 87, No. 7, Year 2006
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Description
The role of CC chemokines in protection against mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission is not well understood. It was observed that mitogen-induced production of CCL3 and CCL4 by cord-blood mononuclear cells was increased among infants born to HIV-positive compared with HIV-negative mothers, and that a deficiency in production of CCL3 was associated with increased susceptibility to intrapartum HIV-1 infection. CCL3-L1 gene copy number was associated with CCL3 production and with vertical transmission. However, at equivalent CCL3-L1 gene copy numbers, infants who acquired HIV-1 infection relative to their exposed but uninfected counterparts had lower production of CCL3, suggesting that they may harbour some non-functional copies of this gene. Nucleotide changes that may influence CCL3 production were evident in the CCL3 and CCL3-L1 genes upstream of exon 2. Our findings suggest that infants who display a deficient-production phenotype of CCL3 are at increased risk of acquiring HIV-1, indicating that this chemokine in particular plays an essential role in protective immunity. © 2006 SGM.
Authors & Co-Authors
Meddows-Taylor, Stephen
South Africa, Johannesburg
University of the Witwatersrand
Donninger, Samantha L.
South Africa, Johannesburg
University of the Witwatersrand
Paximadis, Maria
South Africa, Johannesburg
University of the Witwatersrand
Schramm, Diana B.
South Africa, Johannesburg
University of the Witwatersrand
Anthony, Fiona S.
South Africa, Johannesburg
University of the Witwatersrand
Gray, Glenda E.
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Kuhn, Louise
United States, New York
Columbia University
Tiemessen, Caroline Tanya
South Africa, Johannesburg
University of the Witwatersrand
Statistics
Citations: 64
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1099/vir.0.81709-0
ISSN:
00221317
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health