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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Hypercytokinaemia accompanies HIV-tuberculosis immune reconstitution inflammatory syndrome
European Respiratory Journal, Volume 37, No. 5, Year 2011
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Description
Increased access to combination antiretroviral therapy in areas co-endemic for tuberculosis (TB) and HIV-1 infection is associated with an increased incidence of immune reconstitution inflammatory syndrome (TB-IRIS) whose cause is poorly understood. A case-control analysis of pro- and anti-inflammatory cytokines in TB-IRIS patients sampled at clinical presentation, and similar control patients with HIV-TB prescribed combined antiretroviral therapy who did not develop TB-IRIS. Peripheral blood mononuclear cells were cultured in the presence or absence of heat-killed Mycobacterium tuberculosis for 6 and 24 h. Stimulation with M. tuberculosis increased the abundance of many cytokine transcripts with interleukin (IL)-1β, IL-5, IL-6, IL-10, IL-13, IL-17A, interferon (IFN)-γ, granulocyte-macrophage colony-stimulating factor (GM-CSF) and tumour necrosis factor (TNF) being greater in stimulated TB-IRIS cultures. Analysis of the corresponding proteins in culture supernatants, revealed increased IL-1β, IL-2, IL-6, IL-8, IL-10, IL-12p40, IFN-γ, GM-CSF and TNF in TB-IRIS cultures. In serum, higher concentrations of TNF, IL-6, and IFN-γ were observed in TB-IRIS patients. Serum IL-6 and TNF decreased during prednisone therapy in TB-IRIS patients. These data suggest that cytokine release contributes to pathology in TB-IRIS. IL-6 and TNF were consistently elevated and decreased in serum during corticosteroid therapy. Specific blockade of these cytokines may be rational approach to immunomodulation in TB-IRIS. Copyright©ERS 2011.
Authors & Co-Authors
Tadokera, Rebecca
Unknown Affiliation
Meintjes, Graeme Ayton
Unknown Affiliation
Skolimowska, Keira H.
Unknown Affiliation
Andrea Wilkinson, Katalin Andrea
Unknown Affiliation
Matthews, Kerryn
Unknown Affiliation
Seldon, Ronnett
Unknown Affiliation
Chegou, Novel N.
Unknown Affiliation
Maartens, Gary Tuberculosis
Unknown Affiliation
Rangaka, Molebogeng Xheeda
Unknown Affiliation
Rebe, Kevin Brian
Unknown Affiliation
Walzl, Gerhard
Unknown Affiliation
Wilkinson, Robert J.
Unknown Affiliation
Statistics
Citations: 148
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.1183/09031936.00091010
ISSN:
09031936
e-ISSN:
13993003
Research Areas
Cancer
Health System And Policy
Infectious Diseases
Study Design
Cohort Study
Case-Control Study