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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The left ventricle responds to acute graded elevation of right ventricular afterload by augmentation of twist magnitude and untwist rate
Journal of the American Society of Echocardiography, Volume 24, No. 8, Year 2011
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Description
Background: The right and left ventricles share the interventricular septum, which mechanically transmits pressure gradients. The aim of this study was to investigate how acute mild or moderate right ventricular (RV) afterload affects left ventricular (LV) function. Methods: In 14 open-chest pigs (mean weight, 43 ± 4 kg) with preserved pericardium, acute mild (>35 and ≤50 mm Hg) and moderate (>50 and ≤60 mm Hg) RV pressure loading conditions were induced by constriction of the pulmonary artery. Hemodynamic parameters and LV twist and untwist were evaluated under each condition. Results: From baseline to mild and moderate RV afterload, the mean RV systolic pressure increased from 31.0 ± 4.3 to 41.1 ± 2.7 and 52.7 ± 3.4 mm Hg (P <.001), while LV twist magnitudes increased from 15.4 ± 5.1° to 18.5 ± 3.1° and 19.8 ± 5.0° (P =.004), respectively. Absolute values of LV untwist rate increased from -116.9 ± 64.9°/sec to -160.0 ± 53.3°/sec and -169.1 ± 47.0°/sec, respectively (P =.001). After adjusting for all variables, only the ratio of the early and atrial components of mitral inflow and RV outflow tract acceleration time was significantly associated with the LV twist magnitude and LV untwist rate. Conclusions: In an acute setting, the left ventricle responds to suddenly elevated RV afterload and decreased RV stroke volume by promptly increasing its twist magnitude and untwist rate. © 2011 by the American Society of Echocardiography.
Authors & Co-Authors
Cho, Eun-joo
South Korea, Bucheon-si
The Catholic University of Korea
Jiamsripong, Panupong
United States, Scottsdale
Mayo Clinic Scottsdale-phoenix, Arizona
Calleja, Anna M.
United States, Columbus
Dorothy M. Davis Heart and Lung Research Institute
Alharthi, Mohsen S.
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
McMahon, Eileen M.
United States, Scottsdale
Mayo Clinic Scottsdale-phoenix, Arizona
Chandrasekaran, Krishnaswamy M.D.
United States, Scottsdale
Mayo Clinic Scottsdale-phoenix, Arizona
Cha, Stephen S.
United States, Rochester
Mayo Clinic
Bukatina, Anna Ye
United States, Scottsdale
Mayo Clinic Scottsdale-phoenix, Arizona
Khandheria, Bijoy K.
United States, Milwaukee
Aurora Health Care
Bělohlávek, Marek
United States, Scottsdale
Mayo Clinic Scottsdale-phoenix, Arizona
Statistics
Citations: 10
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1016/j.echo.2011.04.011
ISSN:
08947317
e-ISSN:
10976795
Research Areas
Noncommunicable Diseases