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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Meningococcal group C and W135 immunological hyporesponsiveness in African toddlers
Clinical and Vaccine Immunology, Volume 18, No. 9, Year 2011
Notification
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Description
A phase II clinical study was conducted in African toddlers (aged 12 to 23 months), with subjects receiving either investigational meningococcal group A conjugate (PsA-TT), meningococcal ACWY polysaccharide (PsACWY), or Haemophilus influenzae type b (Hib-TT) vaccine. Ten months following vaccination, the 3 study groups were further randomized to receive a dose of PsA-TT, a 1/5 dose of PsACWY, or a dose of Hib-TT vaccine. Group A serum bactericidal antibody (SBA) results have been reported previously, with PsA-TT demonstrating superior immunogenicity versus PsACWY vaccine. Immunogenicity for serogroups W135 and C was assessed by SBA assay to investigate the impact of multiple doses in this age group. Blood samples were taken prior to vaccination, 28 days and 40 weeks post-primary vaccination, and 7 and 28 days post-booster vaccination with a 1/5 dose of PsACWY. Subjects who had previously received a full dose of PsACWY had W135 SBA geometric mean titers (GMTs) of 26.1 and 4.4 at 7 and 28 days post-booster vaccination with a 1/5 PsACWY dose, respectively, whereas the W135 SBA GMTs of naïve subjects at these time points following vaccination with a 1/5 dose of PsACWY were 861.1 and 14.6, respectively. Similar differences were observed for serogroup C, with SBA GMTs of 99 and 5.9 at 7 and 28 days post-booster vaccination with a 1/5 dose of PsACWY, respectively, for naïve subjects, compared to 4.1 and 3.2 for previously vaccinated subjects. Immunologic hyporesponsiveness for groups C and W135 was observed following a full dose of PsACWY vaccine at 12 to 23 months of age and a 1/5 dose of PsACWY 10 months later compared to the case for PsACWY-naïve subjects receiving a 1/5 dose of PsACWY vaccine. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Findlow, Helen
United Kingdom, London
Public Health England
Sow, Samba Ousmane
Mali, Bamako
Centre Pour le Développement Des Vaccins du Mali Cvd-mali
Borrow, Ray
United Kingdom, London
Public Health England
United Kingdom, Manchester
The University of Manchester
Tapia, Milagritos D.
Mali, Bamako
Centre Pour le Développement Des Vaccins du Mali Cvd-mali
Haidara, Fadima Cheick
Mali, Bamako
Centre Pour le Développement Des Vaccins du Mali Cvd-mali
Akinsola, Adebayo Kolawole
Gambia, Banjul
Medical Research Council Laboratories Gambia
Idoko, Olubukola T.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Diallo, Fatoumata Binta Tidiane
Mali, Bamako
Centre Pour le Développement Des Vaccins du Mali Cvd-mali
Adegbola, Richard A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Tang, Yuxiao
France, Ferney-voltaire
Path
Parulekar, Varsha
India, Mumbai
Diagnosearch Life Sciences
Chadha, Helen
United Kingdom, London
Public Health England
Mabey, Lesley
United Kingdom, London
Public Health England
Holme, Daniel
United Kingdom, London
Public Health England
Townsend, Kelly
United Kingdom, London
Public Health England
Chaumont, Julie
France, Ferney-voltaire
Path
LaForce, F. Marc
France, Ferney-voltaire
Path
Kulkarni, Prasad Suryakant
India, Pune
Serum Institute of India Ltd.
Marchetti, Elisa
France, Ferney-voltaire
Path
Viviani, Simonetta
France, Ferney-voltaire
Path
Hassan-King, Musa K.A.
France, Ferney-voltaire
Path
Préziosi, Marie Pierre
Switzerland, Geneva
Organisation Mondiale de la Santé
Statistics
Citations: 22
Authors: 22
Affiliations: 8
Identifiers
Doi:
10.1128/CVI.05020-11
ISSN:
15566811
e-ISSN:
1556679X