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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Tolerability and safety of primaquine in Papua New Guinean children 1 to 10 years of age
Antimicrobial Agents and Chemotherapy, Volume 56, No. 4, Year 2012
Notification
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Description
Primaquine is currently the only drug available for radical cure of Plasmodium vivax and P. ovale liver infection stages, but limited safety data exist for children <10 years of age. Detailed daily assessments of side effects in glucose-6-phosphate dehydrogenase (G6PD)-normal children treated with 14 days of primaquine plus chloroquine (3 days; n = 252) or artesunate (7 days; n = 141) (0.5 mg/kg of body weight) showed that both treatments are well tolerated, do not lead to reductions in hemoglobin levels, and can thus safely be used in children 1 to 10 years of age. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Betuela, Inoni
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Bassat, Quique
Spain, Barcelona
Instituto de Salud Global de Barcelona
Kiniboro, Benson
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Robinson, Leanne J.
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Rosanas-Urgell, Anna
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Spain, Barcelona
Instituto de Salud Global de Barcelona
Stanisic, Danielle I.
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Siba, Peter Max
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Alonso, Pedro Luís
Spain, Barcelona
Instituto de Salud Global de Barcelona
Mueller, Ivo
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Spain, Barcelona
Instituto de Salud Global de Barcelona
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Statistics
Citations: 20
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1128/AAC.05566-11
ISSN:
10986596
Research Areas
Maternal And Child Health