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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Outbreak of Acinetobacter baumannii in a Neonatal Intensive Care Unit: Antimicrobial Susceptibility and Genotyping Analysis
Annals of Epidemiology, Volume 19, No. 6, Year 2009
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Description
Purpose: We describe an outbreak of nosocomial respiratory infection caused by multi-drug resistant Acinetobacter baumannii in a neonatal intensive care unit (NICU) in Tunis and our investigation to determine the source. Methods: Between May 2006 and February 2007, 31 infants hospitalized in the NICU of the Centre of Maternity and Neonatology of La Rabta in Tunis developed A. baumannii pneumonia. A case (infected infant) was defined as any patient hospitalized in the NICU during the outbreak period, with clinical signs of pneumonia and isolation of A. baumannii from tracheal aspirate. Ten rectal swabs and 98 environmental specimens were collected for the epidemiological investigation. Thirty-nine A. baumannii isolates were collected: 31 clinical strains from tracheal aspirates (>103 colony-forming units [CFU]/mL), 3 environmental strains from incubators, and 5 from rectal swab. For the genotyping method, we used pulsed-field gel electrophoresis using ApaI restriction endonuclease. Results: Thirty-one neonates developed multiple drug-resistant A. baumannii-associated pneumonia with 10 deaths due to A. baumannii infection, 48.4% had very low birth weight (≤1500 g), and 67.7% neonates were premature. The mean age at the beginning of symptoms was 6.9 days. A. baumannii isolates were resistant to all β-lactams. Resistance rates to other antibiotics were, respectively, 94.9% for gentamicin, 87.2% for cotrimoxazole, 41% for netilmicin, and 5.1% for tobramycin. All the isolates were susceptible to colistin. Pulsed-field gel electrophoresis analysis of outbreak-isolates indicated the presence of only one clone (A) containing nine subtypes genetically related to the outbreak strain. Conclusion: The clonal diffusion of A. baumannii strains in an NICU was confirmed by molecular method. Control measures were reinforced to contain the outbreak. © 2009 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Touati, Arabella
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Achour, W.
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Chérif, Ahmed
Tunisia, Tunis
Université de Tunis el Manar, Centre de Maternité et de Néonatologie
Hmida, Hayet Ben
Tunisia, Tunis
Université de Tunis el Manar, Centre de Maternité et de Néonatologie
Afif, Firas Bou
Tunisia, Tunis
Université de Tunis el Manar, Centre de Maternité et de Néonatologie
Jabnoun, Sami
Tunisia, Tunis
Université de Tunis el Manar, Centre de Maternité et de Néonatologie
Khrouf, Naïma
Tunisia, Tunis
Université de Tunis el Manar, Centre de Maternité et de Néonatologie
Ben Hassen, Assia
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Statistics
Citations: 65
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1016/j.annepidem.2009.03.010
ISSN:
10472797
Research Areas
Health System And Policy
Maternal And Child Health