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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Serotype-specific pneumococcal disease may be influenced by mannose-binding lectin deficiency
European Respiratory Journal, Volume 36, No. 4, Year 2010
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Description
Previous studies of the association between the mannose-binding lectin pathway deficiencies and invasive pneumococcal disease are inconclusive. Invasiveness of Streptococcus pneumoniae is dependent on serotype. We aimed to determine the association between invasive pneumococcal disease and MBL2 and MASP2 genetic variants, regarding serotype distribution. A hospital-based case-control study was conducted in children admitted to hospital in rural Mozambique in June 2002-November 2003. The study included children admitted to hospital with invasive pneumococcal disease, in whom S. pneumoniae was isolated from blood and subsequently serotyped. Sequence-based typing analysis of amplicons covering the polymorphic regions of MASP2 (exon 3) and MBL2 (promoter and exon 1) was performed. An overall high frequency of MBL2 genotypes associated with low serum levels of MBL (43%) was found. Carriers of MBL-deficient genotypes were associated with invasive pneumococcal disease produced by low-invasive serotypes (OR 5.55, 95% CI 1.4-21.9; p=0.01). Our data suggest that susceptibility to pneumococcal disease among MBL-deficient patients may be influenced by serotype invasiveness. Type-specific capsular serotype of S. pneumoniae would need to be taken into account in further genetic association studies of invasive pneumococcal disease. Copyright©ERS 2010.
Authors & Co-Authors
Vallès, Xavier
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Spain, Barcelona
Hospital Clinic Barcelona
Spain, Barcelona
Universitat de Barcelona
Roca, Anna
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Spain, Barcelona
Universitat de Barcelona
Lozano, Francisco
Spain, Barcelona
Universitat de Barcelona
Morais, Luís
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Suárez, Belén Crespo
Spain, Barcelona
Universitat de Barcelona
Casals, Ferran
Spain, Barcelona
Csic-upf - Instituto de Biologia Evolutiva Ibe
Mandomando, Inácio M.
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mozambique, Maputo
Instituto Nacional de Saude Maputo
Sigaúque, Betuel
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mozambique, Maputo
Instituto Nacional de Saude Maputo
Nhalungo, Delino A.
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Esquinas, Cristina
Spain, Barcelona
Hospital Clinic Barcelona
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
Quintò, Llorenç L.
Spain, Barcelona
Universitat de Barcelona
Alonso, Pedro Luís
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Spain, Barcelona
Universitat de Barcelona
Torres, Antoni
Spain, Barcelona
Hospital Clinic Barcelona
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
Statistics
Citations: 15
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1183/09031936.00171409
ISSN:
09031936
e-ISSN:
13993003
Research Areas
Genetics And Genomics
Health System And Policy
Maternal And Child Health
Study Design
Case-Control Study
Study Locations
Mozambique