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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Plasmodium falciparum merozoite surface antigen, PfRH5, elicits detectable levels of invasion-inhibiting antibodies in humans
Journal of Infectious Diseases, Volume 208, No. 10, Year 2013
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Description
Plasmodium falciparum is an intracellular protozoan parasite that infects erythrocytes and hepatocytes. The blood stage of its life cycle causes substantial morbidity and mortality associated with millions of infections each year, motivating an intensive search for potential components of a multi-subunit vaccine. In this study, we present data showing that antibodies from natural infections can recognize a recombinant form of the relatively conserved merozoite surface antigen, PfRH5. Furthermore, we performed invasion inhibition assays on clinical isolates and laboratory strains of P. falciparum in the presence of affinity purified antibodies to RH5 and show that these antibodies can inhibit invasion in vitro. © The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3805239/bin/supp_208_10_1679__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3805239/bin/supp_jit385_jit385supp.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3805239/bin/supp_jit385_jit385supp_fig1.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3805239/bin/supp_jit385_jit385supp_fig2.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3805239/bin/supp_jit385_jit385supp_fig3.tif
Authors & Co-Authors
Patel, Saurabh D.
United States, Boston
Boston Children's Hospital
United States, Chevy Chase
Howard Hughes Medical Institute
Ahouidi, Ambroise Dioum
United States, Boston
Boston Children's Hospital
United States
Le Dantec Hospital
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Bei, Amy Kristine
United States, Boston
Boston Children's Hospital
United States
Le Dantec Hospital
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Diéye, Tandakha Ndiaye D.
United States
Le Dantec Hospital
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Mboup, Souleymane
United States
Le Dantec Hospital
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Harrison, Stephen C.
United States, Chevy Chase
Howard Hughes Medical Institute
Duraisingh, Manoj Theodore
United States, Boston
Boston Children's Hospital
Statistics
Citations: 67
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1093/infdis/jit385
ISSN:
00221899