Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Delayed-type hypersensitivity skin tests are an independent predictor of human immunodeficiency virus disease progression
Journal of Infectious Diseases, Volume 169, No. 4, Year 1994
Notification
URL copied to clipboard!
Description
Delayed-type hypersensitivity (DTH) testing was evaluated as a predictor of human immunodeficiency virus (HIV) disease progression in 336 symptomatic patients with baseline CD4 cell counts of 200-500/mm3 who were participating in a randomized trial ofearly versus late therapy with zidovudine. Patients with a response of >2 mm to any of seven antigens were categorized as reactive; those without were anergic. Anergic patients were significantly more likely than reactive patients to have HIV disease progression as evidenced by decrease in CD4 cell count (52% vs. 27%), development ofAIDS (33% vs. 17%), or death (18% vs. 9%) (P ≤.02), irrespective oftime of zidovudine initiation. By multivariate analysis, DTH results were an independent predictor of HIV progression separate from CD4 cell count, p24 antigen positivity, or level ofPrmicroglobulin. DTH skin tests are an independent predictor of HIV disease progression and may be ofvalue in the evaluation of a patient's immune status. © 1994 by The University of Chicago.
Authors & Co-Authors
Hamilton, John David
United States
Va Medical Center
Lahart, Christopher J.
United States
Va Medical Center
Musher, Daniel M.
United States
Va Medical Center
Marovich, Mary Anne
United States, Bethesda
Walter Reed National Military Medical Center
Ziegler, John L.
United States, Bethesda
Walter Reed National Military Medical Center
Oster, Charles N.
United States
Va Medical Center
Cross, Anne P.
United States
Va Medical Center
van der Horst, Charles Michael
Unknown Affiliation
Weinhold, Kent J.
Unknown Affiliation
Statistics
Citations: 65
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1093/infdis/169.4.893
ISSN:
00221899
Research Areas
Health System And Policy
Infectious Diseases