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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Substituted thiazoles VI. Synthesis and antitumor activity of new 2-acetamido- and 2 or 3-propanamido-thiazole analogs
European Journal of Medicinal Chemistry, Volume 54, Year 2012
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Description
A novel series of 2-acetamido and 2 or 3-propanamido derivatives of 4- or 5-substituted-thiazoles was designed and synthesized. Structure elucidation of the new synthesized compounds was attained by the use of 1H & 13C NMR, and Mass spectrometry. Compounds were subjected to NCI in vitro assessment for their antitumor activity, at a single dose of 10 μM of test compounds. Compounds bearing straight chain substituent or 4-phenyl function proved to be more active than their branched or 4-methyl congeners. Compounds 37, 41 and 42 exhibited broad spectrum antitumor activity. Compounds 23 and 27 proved lethal while compounds 18, 21, 32 and 37 showed remarkable GI values of 75.5, 69.3, 96.2 and 92.7% to the Leukemia CCRF-CEM cell line, respectively. © 2012 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
El-Messery, Shahenda M.
Egypt, Mansoura
Faculty of Pharmacy
Hassan, Ghada S.
Saudi Arabia, Riyadh
College of Pharmacy
Egypt, Mansoura
Mansoura University
Al-Omary, Fatmah Abdulaziz M.
Saudi Arabia, Riyadh
College of Pharmacy
El-Subbagh, Hussein I.
Egypt, New Cairo
Future University in Egypt
Statistics
Citations: 54
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1016/j.ejmech.2012.06.013
ISSN:
02235234
e-ISSN:
17683254