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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Potential role of sylvatic and domestic African mosquito species in dengue emergence
American Journal of Tropical Medicine and Hygiene, Volume 73, No. 2, Year 2005
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Description
Dengue virus 2 (DENV-2) strains that circulate in sylvatic habitats of Senegal and other parts of west Africa are believed to represent ancestral forms that evolved into endemic/epidemic strains that now circulate widely in urban areas of the tropics. Previous studies suggested that the evolution of the endemic/epidemic strains was mediated by adaptation to the peridomestic mosquito vectors Aedes aegypti and Ae. albopictus. We conducted experimental infections using sylvatic and peridomestic Senegalese mosquitoes, and both sylvatic and urban DENV-2 strains to determine if endemic DENV-2 adaptation was vector species specific, and to assess ancestral vector susceptibility. Aedes furcifer and Ae. luteocephalus, probable sylvatic vectors, were highly susceptible to both sylvatic and urban DENV-2 strains. In contrast, sylvatic Ae. vittatus and both sylvatic and peridomestic populations of Ae. aegypti were relative refractory to all DENV-2 strains tested. These results indicate that adaptation of DENV-2 to urban vectors did not result in a loss of infectivity for some African sylvatic vectors. Implications for dengue emergence in west Africa are discussed. Copyright © 2005 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Diallo, Mawlouth R.
Senegal, Dakar
Institut Pasteur de Dakar
Sall, Amadou Alpha
Senegal, Dakar
Institut Pasteur de Dakar
Moncayo, Abelardo C.
United States, Nashville
Tennessee Department of Health
Bâ, Yamar
Senegal, Dakar
Institut Pasteur de Dakar
Fernandez, Zoraida
Venezuela, Altos de Pipe
Instituto Venezolano de Investigaciones Científicas
Ortiz, Diana
United States, Galveston
University of Texas Medical Branch, School of Medicine
Coffey, Lark L.A.
United States, Galveston
University of Texas Medical Branch, School of Medicine
Mathiot, Christian C.
Switzerland, Geneva
Organisation Mondiale de la Santé
Tesh, Robert B.
United States, Galveston
University of Texas Medical Branch, School of Medicine
Weaver, Scott C.
United States, Galveston
University of Texas Medical Branch, School of Medicine
Statistics
Citations: 112
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.4269/ajtmh.2005.73.445
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Study Locations
Multi-countries
Senegal